Granitoid rocks of the compositionally zoned Late Cretaceous Toulumne Intrusive Suite in the central Sierra Nevada, California, have initial87Sr/86Sr values (Sri) and143Nd/144Nd values (Ndi) that vary from 0.7057 to 0.7067 and from 0.51239 to 0.51211 respectively. The observed variation of both Sri and Ndi and of chemical composition in rocks of the suite cannot be due to crystal fractionation of magma solely under closed system conditons. The largest variation in chemistry, Ndi, and Sri is present in the outer-most equigranular units of the Tuolumne Intrusive Suite. Sri varies positively with SiO2, Na2O, K2O, and Rb concentrations, and negatively with Ndi, Al2O3, Fe2O3, MgO, FeO, CaO, MnO, P2O5, TiO2, and Sr concentrations. This covariation of Sri, Ndi and chemistry can be modeled by a process of simple mixing of basaltic and granitic magmas having weight percent SiO2 of 48.0 and 73.3 respectively. Isotopic characteristic of the mafic magma are Sri=0.7047, Ndi=0.51269 and δ18O=6.0, and of the felsic magma are Sri=0.7068, Ndi=0.51212 and δ18O=8.9. The rocks sampled contain from 50 to 80% of the felsic component. An aplite in the outer equigranular unit of the Tuolumne Intrusive Suite apparently was derived by fractional crystallization of plagioclase and hornblende from magma with granudiorite composition that was a product of mixing of the magmas described above. Siliceous magmas derived from the lower crust, having a maximum of 15 percent mantle-derived mafic component, are represented by the inner prophyritic units of the Tuolumne Intrusive Suite.