Issues in recruiting community-dwelling stroke survivors to clinical trials

The AMBULATE trial

Gemma Lloyd, Catherine M. Dean*, Louise Ada

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Recruitment to clinical trials is often slow and difficult, with a growing body of research examining this issue. However there is very little work related to stroke. Aims: The aim of this study was to examine the success and efficiency of recruitment of community-dwelling stroke survivors over the first two years of a clinical trial aiming to improve community ambulation. Method: Recruitment strategies fell into 2 broad categories: (i) advertisement (such as newspaper advertising and media releases), and (ii) referral (via hospital and community physiotherapists, a stroke liaison officer and other researchers). Records were kept of the number of people who were screened, were eligible and were recruited for each strategy. Results: The recruitment target of 60 in the first two years was not met. 111 stroke survivors were screened and 57 were recruited (i.e., a recruitment rate of 51%). The most successful strategy was referral via hospital-based physiotherapists (47% of recruited participants) and the least successful were media release and local newspaper advertising. The referral strategies were all more efficient than any of the advertisement strategies. Conclusions: In general, recruitment was inefficient and costly in terms of human resources. Given that stroke research is underfunded, it is important to find efficient ways of recruiting stroke survivors to clinical trials. An Australian national database similar to other disease-specific data bases (such as the National Cancer Database) is under development. In the interim, recruiting for several clinical trials at once may increase efficiency.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalContemporary Clinical Trials
Volume31
Issue number4
DOIs
Publication statusPublished - Jul 2010
Externally publishedYes

Keywords

  • Cerebrovascular disorders
  • Eligibility determination
  • Patient selection
  • Randomized controlled trial
  • Stroke

Fingerprint Dive into the research topics of 'Issues in recruiting community-dwelling stroke survivors to clinical trials: The AMBULATE trial'. Together they form a unique fingerprint.

Cite this