iSwathX: an interactive web-based application for extension of DIA peptide reference libraries

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Abstract

Large-scale peptide mass spectrometry (MS)/MS reference libraries are essential for the comprehensive analysis of data-independent acquisition (DIA) MS datasets, providing a comprehensive set of spectra for identification and quantification of proteins. We have developed a novel web-based R-package (iSwathX) for combining reference libraries that is compatible with different DIA analysis software. This open-source web GUI automates the process of normalization and combination of spectral libraries and provides a user-friendly method for performing library format conversions, analysis and visualizations, with no need for programing familiarity.
LanguageEnglish
Pages538-539
Number of pages2
JournalBioinformatics
Volume35
Issue number3
DOIs
Publication statusPublished - 1 Feb 2019

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Peptide Library
Peptides
Web-based
Libraries
Mass Spectrometry
Mass spectrometry
Graphical user interfaces
Tandem Mass Spectrometry
Open Source
Quantification
Normalization
Software
Visualization
Proteins
Protein
Acquisition

Cite this

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abstract = "Large-scale peptide mass spectrometry (MS)/MS reference libraries are essential for the comprehensive analysis of data-independent acquisition (DIA) MS datasets, providing a comprehensive set of spectra for identification and quantification of proteins. We have developed a novel web-based R-package (iSwathX) for combining reference libraries that is compatible with different DIA analysis software. This open-source web GUI automates the process of normalization and combination of spectral libraries and provides a user-friendly method for performing library format conversions, analysis and visualizations, with no need for programing familiarity.",
author = "Zainab Noor and Wu, {Jemma X.} and Dana Pascovici and Abidali Mohamedali and Molloy, {Mark P.} and Baker, {Mark S.} and Shoba Ranganathan",
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AU - Baker, Mark S.

AU - Ranganathan, Shoba

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