iSwathX: an interactive web-based application for extension of DIA peptide reference libraries

Zainab Noor; Jemma X. Wu; Dana Pascovici; Abidali Mohamedali; Mark P. Molloy; Mark S. Baker; Shoba Ranganathan

doi:10.1093/bioinformatics/bty660

iSwathX: an interactive web-based application for extension of DIA peptide reference libraries

Zainab Noor, Jemma X. Wu, Dana Pascovici, Abidali Mohamedali, Mark P. Molloy, Mark S. Baker, Shoba Ranganathan

Australian Proteome Analysis Facility (APAF)

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Large-scale peptide mass spectrometry (MS)/MS reference libraries are essential for the comprehensive analysis of data-independent acquisition (DIA) MS datasets, providing a comprehensive set of spectra for identification and quantification of proteins. We have developed a novel web-based R-package (iSwathX) for combining reference libraries that is compatible with different DIA analysis software. This open-source web GUI automates the process of normalization and combination of spectral libraries and provides a user-friendly method for performing library format conversions, analysis and visualizations, with no need for programing familiarity.

Original language	English
Pages (from-to)	538-539
Number of pages	2
Journal	Bioinformatics
Volume	35
Issue number	3
DOIs	https://doi.org/10.1093/bioinformatics/bty660
Publication status	Published - 1 Feb 2019

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10.1093/bioinformatics/bty660

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iSwathX: an interactive web-based application for extension of DIA peptide reference libraries

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