Joint modelling of survival and cognitive decline in the Australian Longitudinal Study of Ageing

Petra L. Graham; Louise M. Ryan; Mary A. Luszcz

doi:10.1111/j.1467-9876.2010.00737.x

Joint modelling of survival and cognitive decline in the Australian Longitudinal Study of Ageing

Petra L. Graham^*, Louise M. Ryan, Mary A. Luszcz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The paper describes the use of a longitudinal tobit model to characterize cognitive decline over a 13-year period in a cohort of 2087 elderly Australians. Use of a tobit formulation allows for the so-called 'ceiling effect' wherein many subjects achieve perfect test scores. A Bayesian hierarchical joint model is presented that allows for random subject-specific intercepts and slopes, as well as for informative dropout. Results suggest several potential areas of intervention. For example, there is a clear dose-response effect of exercise whereby increasing levels of exercise are associated with higher cognitive scores.

Original language	English
Pages (from-to)	221-238
Number of pages	18
Journal	Journal of the Royal Statistical Society. Series C: Applied Statistics
Volume	60
Issue number	2
DOIs	https://doi.org/10.1111/j.1467-9876.2010.00737.x
Publication status	Published - Mar 2011

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10.1111/j.1467-9876.2010.00737.x

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Joint modelling of survival and cognitive decline in the Australian Longitudinal Study of Ageing

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