Junctional neural tube defect

Sebastian Eibach, Dachling Pang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
6 Downloads (Pure)


Junctional neurulation represents the most recent adjunct to the well-known sequential embryological processes of primary and secondary neurulation. While its exact molecular processes, occurring at the end of primary and the beginning of secondary neurulation, are still being actively investigated, its pathological counterpart –junctional neural tube defect (JNTD)– had been described in 2017 based on three patients whose well-formed secondary neural tube, the conus, is widely separated from its corresponding primary neural tube and functionally disconnected from corticospinal control from above. Several other cases conforming to this bizarre neural tube arrangement have since appeared in the literature, reinforcing the validity of this entity. The cardinal clinical, neuroimaging, and electrophysiological features of JNTD, and the hypothesis of its embryogenetic mechanism, form part of this review.

Original languageEnglish
Pages (from-to)327-337
Number of pages11
JournalJournal of Korean Neurosurgical Society
Issue number3
Publication statusPublished - May 2020

Bibliographical note

Copyright the Korean Neurosurgical Society 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • Embryology
  • Neural tube defects
  • Neurulation
  • Spinal dysraphism


Dive into the research topics of 'Junctional neural tube defect'. Together they form a unique fingerprint.

Cite this