Abstract
Kainic acid injected into rat nucleus tractus solitarius (NTS) caused a slowly developing hypertension, with a 2-fold increase in Fos-immunoreactive (Fos-IR) nuclei in the area of the presympathetic bulbospinal neurons in the rostral ventrolateral medulla (RVLM) and a widespread activation of sympathetic preganglionic neurons (SPN) in the spinal cord, particularly in the mid to lower thoracic cord. The highest segmental concentration of Fos-IR SPN was in T8, with Fos-IR nuclei increased 12-fold compared with the vehicle injected group. More than 60% of retro-gradely labelled sympathoadrenal neurons in T8 were Fos-IR after kainic acid injection, consistent with the 60-fold increases in plasma adrenaline levels observed in these rats.
Original language | English |
---|---|
Pages (from-to) | 437-440 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 3 |
Issue number | 5 |
Publication status | Published - 1992 |
Keywords
- Blood pressure
- Fos-immunoreactivity
- Intermediolateral cell column
- Retrograde tracing
- Sympathetic preganglionic neuron
- Ventrolateral medulla