Ketamine cystitis as a mimic of carcinoma in situ

Jon D. Oxley; Angela M. Cottrell; Susan Adams; David Gillatt

doi:10.1111/j.1365-2559.2009.03437.x

Ketamine cystitis as a mimic of carcinoma in situ

Jon D. Oxley, Angela M. Cottrell, Susan Adams, David Gillatt

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Aims: To describe the histopathological features of a series of patients with ketamine-related cystitis. Methods and results: Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20. Conclusions: Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown. Journal compilation

Original language	English
Pages (from-to)	705-708
Number of pages	4
Journal	Histopathology
Volume	55
Issue number	6
DOIs	https://doi.org/10.1111/j.1365-2559.2009.03437.x
Publication status	Published - Dec 2009
Externally published	Yes

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10.1111/j.1365-2559.2009.03437.x

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title = "Ketamine cystitis as a mimic of carcinoma in situ",

abstract = "Aims: To describe the histopathological features of a series of patients with ketamine-related cystitis. Methods and results: Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20. Conclusions: Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown. Journal compilation",

author = "Oxley, {Jon D.} and Cottrell, {Angela M.} and Susan Adams and David Gillatt",

year = "2009",

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doi = "10.1111/j.1365-2559.2009.03437.x",

language = "English",

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AU - Oxley, Jon D.

AU - Cottrell, Angela M.

AU - Adams, Susan

AU - Gillatt, David

PY - 2009/12

Y1 - 2009/12

N2 - Aims: To describe the histopathological features of a series of patients with ketamine-related cystitis. Methods and results: Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20. Conclusions: Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown. Journal compilation

AB - Aims: To describe the histopathological features of a series of patients with ketamine-related cystitis. Methods and results: Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20. Conclusions: Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown. Journal compilation

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VL - 55

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JO - Histopathology

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Ketamine cystitis as a mimic of carcinoma in situ

Abstract

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