Ketamine cystitis as a mimic of carcinoma in situ

Jon D. Oxley, Angela M. Cottrell, Susan Adams, David Gillatt

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)


Aims: To describe the histopathological features of a series of patients with ketamine-related cystitis. Methods and results: Seventeen patients with ketamine-related cystitis, who had undergone biopsy, were identified and reviewed. Twelve showed ulceration with significant urothelial atypia. In 10 of these, immunohistochemistry was performed; 9/10 had high p53 immunoreactivity and 7/10 had moderate to high levels of Ki67 reactivity, but all were negative for cytokeratin 20. Conclusions: Ketamine can lead to reactive urothelial changes that can mimic carcinoma in situ, but the long-term cancer risk remains unknown. Journal compilation

Original languageEnglish
Pages (from-to)705-708
Number of pages4
Issue number6
Publication statusPublished - Dec 2009
Externally publishedYes


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