K3 killer yeast is a mutant K2 killer yeast

Brenda D. Wingfield*, Linda J. Van Der Meer, Isak S. Pretorius, Hendrik J J Van Vuuren

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The K2 and K3 killer yeast classes in Saccharomyces cerevisiae were compared. Sensitive strain 381 and the killer strains NCYC 232 NCYC 190, NCYC 738, NCYC 761 and KT28 were sensitive to the killer toxins produced by the K2 and K3 strains. However, these two strains were resistant to both toxins. Hybridization analysis showed that the M dsRNAs from the K2 and K3 strains had significant homology, but shared no homology with the dsRNAs from the K1 and KT28 strains. The K2 M dsRNA is larger than the K3 M dsRNA, and electron micrographs showed an unmatched loop when these molecules were hybridized. This suggests that the K3 M dsRNA is a mutant K2 M genome. These results show that K2 and K3 strains belong in the same class, but separate from the K1 and KT28 killer ty

Original languageEnglish
Pages (from-to)901-906
Number of pages6
JournalMycological Research
Issue number7
Publication statusPublished - 1990
Externally publishedYes


  • dsRNA
  • Killer yeast
  • Saccharomyces cerevisiae


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