Kumbicins A-D

Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius

Heather J. Lacey, Daniel Vuong, John I. Pitt, Ernest Lacey, Andrew M. Piggott*

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A soil survey conducted in southern Queensland, Australia, identified a novel isolate belonging to the genus Aspergillus subgenus Circumdati section Circumdati, Aspergillus kumbius FRR6049. Cultivation and fractionation of secondary metabolites from A. kumbius revealed a unique chemotype comprising three new bis-indolyl benzenoids, kumbicins A-C, and a new bis-indolyl benzoquinone, kumbicin D, along with the previously reported compounds asterriquinol D dimethyl ether, petromurins C and D, aspochracin, its N-demethyl analogue JBIR-15, and neohydroxyaspergillic acid. The structures of kumbicins A-D were assigned by detailed spectroscopic analysis. Kumbicin C was found to inhibit the growth of mouse myeloma cells (IC50 0.74 μgmL-1) and the Gram-positive bacterium Bacillus subtilis (MIC 1.6 μgmL-1).

Original languageEnglish
Pages (from-to)152-160
Number of pages9
JournalAustralian Journal of Chemistry
Volume69
Issue number2
DOIs
Publication statusPublished - 2016

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