Kumbicins A-D: Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius

Heather J. Lacey; Daniel Vuong; John I. Pitt; Ernest Lacey; Andrew M. Piggott

doi:10.1071/CH15488

Kumbicins A-D

Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius

Heather J. Lacey, Daniel Vuong, John I. Pitt, Ernest Lacey, Andrew M. Piggott^*

^*Corresponding author for this work

Department of Molecular Sciences

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

A soil survey conducted in southern Queensland, Australia, identified a novel isolate belonging to the genus Aspergillus subgenus Circumdati section Circumdati, Aspergillus kumbius FRR6049. Cultivation and fractionation of secondary metabolites from A. kumbius revealed a unique chemotype comprising three new bis-indolyl benzenoids, kumbicins A-C, and a new bis-indolyl benzoquinone, kumbicin D, along with the previously reported compounds asterriquinol D dimethyl ether, petromurins C and D, aspochracin, its N-demethyl analogue JBIR-15, and neohydroxyaspergillic acid. The structures of kumbicins A-D were assigned by detailed spectroscopic analysis. Kumbicin C was found to inhibit the growth of mouse myeloma cells (IC₅₀ 0.74 μgmL^-1) and the Gram-positive bacterium Bacillus subtilis (MIC 1.6 μgmL^-1).

Original language	English
Pages (from-to)	152-160
Number of pages	9
Journal	Australian Journal of Chemistry
Volume	69
Issue number	2
DOIs	https://doi.org/10.1071/CH15488
Publication status	Published - 2016

Bibliographical note

Copyright the Publisher 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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Lacey, H. J., Vuong, D., Pitt, J. I., Lacey, E., & Piggott, A. M. (2016). Kumbicins A-D: Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius. Australian Journal of Chemistry, 69(2), 152-160. https://doi.org/10.1071/CH15488

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abstract = "A soil survey conducted in southern Queensland, Australia, identified a novel isolate belonging to the genus Aspergillus subgenus Circumdati section Circumdati, Aspergillus kumbius FRR6049. Cultivation and fractionation of secondary metabolites from A. kumbius revealed a unique chemotype comprising three new bis-indolyl benzenoids, kumbicins A-C, and a new bis-indolyl benzoquinone, kumbicin D, along with the previously reported compounds asterriquinol D dimethyl ether, petromurins C and D, aspochracin, its N-demethyl analogue JBIR-15, and neohydroxyaspergillic acid. The structures of kumbicins A-D were assigned by detailed spectroscopic analysis. Kumbicin C was found to inhibit the growth of mouse myeloma cells (IC50 0.74 μgmL-1) and the Gram-positive bacterium Bacillus subtilis (MIC 1.6 μgmL-1).",

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