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Abstract
A soil survey conducted in southern Queensland, Australia, identified a novel isolate belonging to the genus Aspergillus subgenus Circumdati section Circumdati, Aspergillus kumbius FRR6049. Cultivation and fractionation of secondary metabolites from A. kumbius revealed a unique chemotype comprising three new bis-indolyl benzenoids, kumbicins A-C, and a new bis-indolyl benzoquinone, kumbicin D, along with the previously reported compounds asterriquinol D dimethyl ether, petromurins C and D, aspochracin, its N-demethyl analogue JBIR-15, and neohydroxyaspergillic acid. The structures of kumbicins A-D were assigned by detailed spectroscopic analysis. Kumbicin C was found to inhibit the growth of mouse myeloma cells (IC50 0.74 μgmL-1) and the Gram-positive bacterium Bacillus subtilis (MIC 1.6 μgmL-1).
Original language | English |
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Pages (from-to) | 152-160 |
Number of pages | 9 |
Journal | Australian Journal of Chemistry |
Volume | 69 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2016 |
Bibliographical note
Copyright the Publisher 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Fingerprint
Dive into the research topics of 'Kumbicins A-D: Bis-Indolyl Benzenoids and Benzoquinones from an Australian Soil Fungus, Aspergillus kumbius'. Together they form a unique fingerprint.Projects
- 1 Finished
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Overcoming antibiotic resistance: rapid discovery of new antibacterial drug targets using chemicalproteomics
Piggott, A., MQRES, M. & MQRES (International), M. (.
7/04/14 → 6/04/18
Project: Research