TY - JOUR
T1 - Kynurenine pathway in skin cells
T2 - Implications for UV-induced skin damage
AU - Sheipouri, Diba
AU - Braidy, Nady
AU - Guillemin, Gilles J.
N1 - Copyright the Author(s) 2012. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2012
Y1 - 2012
N2 - The kynurenine pathway (KP) is the principle route of catabolism of the essential amino acid tryptophan, leading to the production of several neuroactive and immunoregulatory metabolites. Alterations in the KP have been implicated in various neuropsychiatric and neurodegenerative diseases, immunological disorders, and many other diseased states. Although the role of the KP in the skin has been evaluated in small niche fields, limited studies are available regarding the effect of acute ultra violet exposure and the induction of the KP in human skin-derived fibroblasts and keratinocytes. Since UV exposure can illicit an inflammatory component in skin cells, it is highly likely that the KP may be induced in these cells in response to UV exposure. It is also possible that some KP metabolites may act as pro-inflammatory and anti-inflammatory mediators, since the KP is important in immunomodulation.
AB - The kynurenine pathway (KP) is the principle route of catabolism of the essential amino acid tryptophan, leading to the production of several neuroactive and immunoregulatory metabolites. Alterations in the KP have been implicated in various neuropsychiatric and neurodegenerative diseases, immunological disorders, and many other diseased states. Although the role of the KP in the skin has been evaluated in small niche fields, limited studies are available regarding the effect of acute ultra violet exposure and the induction of the KP in human skin-derived fibroblasts and keratinocytes. Since UV exposure can illicit an inflammatory component in skin cells, it is highly likely that the KP may be induced in these cells in response to UV exposure. It is also possible that some KP metabolites may act as pro-inflammatory and anti-inflammatory mediators, since the KP is important in immunomodulation.
UR - http://www.scopus.com/inward/record.url?scp=84877880506&partnerID=8YFLogxK
U2 - 10.4137/IJTR.S9835
DO - 10.4137/IJTR.S9835
M3 - Review article
C2 - 22837645
AN - SCOPUS:84877880506
SN - 1178-6469
VL - 5
SP - 15
EP - 25
JO - International Journal of Tryptophan Research
JF - International Journal of Tryptophan Research
IS - 1
ER -