Lack of effect of enalaprilat on the action of vasoactive intestinal polypeptide in the human forearm.

JR Cockcroft*, P. Chowienczyk, TG Elliott, JM Ritter

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It has been proposed that angiotensin converting enzyme (ACE) may play a role in the metabolism of the vasodilator peptide vasoactive intestinal polypeptide (VIP). Reduced metabolism following treatment with ACE inhibitors may cause accumulation of VIP which in turn may mediate some of the beneficial haemodynamic effects of ACE inhibition observed in patients with heart failure. This study has shown that inhibition of local vascular ACE does not interfere with the vascular effects of VIP on forearm resistance vessels when this peptide is infused into the brachial artery of normal volunteers. These results suggest that endothelial ACE plays little part in the metabolism of intravascular VIP. 1993 The British Pharmacological Society

Original languageEnglish
Pages (from-to)525-527
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Volume35
Issue number5
DOIs
Publication statusPublished - 1993

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