Laminar wall shear stress in brain arteriovenous malformations: systematic review of literature

Anna Lo Presti, Jeffrey M. Rogers, Marcus A. Stoodley, Nazih N. A. Assaad, Mary Simons, Itsu Sen, Michael Kerin Morgan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Laminar wall sheer stress (LWSS) modulates inflammatory activity of the endothelium and may be a contributing factor in many cerebrovascular pathologies. There is a lack of consensus whether significant differences in LWSS exist between feeding vessels in brain arteriovenous malformation (bAVM) and healthy vessels. A systematic review of LWSS research in bAVM was undertaken, including the methods used and the assumptions made in determining LWSS. Methods: Ovid MEDLINE, EMBASE, and Scopus electronic databases were systematically searched from inception for articles calculating LWSS in bAVM cases. LWSS values were extracted for comparison between ipsilateral bAVM feeding arteries and healthy contralateral vessels or healthy normative data. Results: Three retrospective cohort studies were identified, reporting on 42 adult and pediatric bAVM cases. Mean LWSS (mLWSS) in healthy vessels (contralateral vessels or normative controls) typically ranged from 1.2–2.7 Pa, while mLWSS values in untreated bAVM feeding arteries typically ranged from 1.6–3.6 Pa. All studies had mixed cohorts of ruptured and unruptured cases, obscuring the relationship between LWSS and bAVM history. Conclusions: mLWSS values in healthy arteries and bAVM feeding vessels tend to be low and overlapping. Further research of high scientific and methodologic quality is necessary to improve understanding of how LWSS hemodynamics relate to bAVM formation, rupture, and treatment.

LanguageEnglish
Pagese760-e767
Number of pages8
JournalWorld Neurosurgery
Volume128
DOIs
Publication statusPublished - 1 Aug 2019

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Arteriovenous Malformations
Brain
Arteries
Research
MEDLINE
Endothelium
Rupture
Cohort Studies
Retrospective Studies
Hemodynamics
History
Databases
Pediatrics
Pathology

Cite this

Lo Presti, Anna ; Rogers, Jeffrey M. ; Stoodley, Marcus A. ; Assaad, Nazih N. A. ; Simons, Mary ; Sen, Itsu ; Morgan, Michael Kerin. / Laminar wall shear stress in brain arteriovenous malformations : systematic review of literature. In: World Neurosurgery. 2019 ; Vol. 128. pp. e760-e767.
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abstract = "Background: Laminar wall sheer stress (LWSS) modulates inflammatory activity of the endothelium and may be a contributing factor in many cerebrovascular pathologies. There is a lack of consensus whether significant differences in LWSS exist between feeding vessels in brain arteriovenous malformation (bAVM) and healthy vessels. A systematic review of LWSS research in bAVM was undertaken, including the methods used and the assumptions made in determining LWSS. Methods: Ovid MEDLINE, EMBASE, and Scopus electronic databases were systematically searched from inception for articles calculating LWSS in bAVM cases. LWSS values were extracted for comparison between ipsilateral bAVM feeding arteries and healthy contralateral vessels or healthy normative data. Results: Three retrospective cohort studies were identified, reporting on 42 adult and pediatric bAVM cases. Mean LWSS (mLWSS) in healthy vessels (contralateral vessels or normative controls) typically ranged from 1.2–2.7 Pa, while mLWSS values in untreated bAVM feeding arteries typically ranged from 1.6–3.6 Pa. All studies had mixed cohorts of ruptured and unruptured cases, obscuring the relationship between LWSS and bAVM history. Conclusions: mLWSS values in healthy arteries and bAVM feeding vessels tend to be low and overlapping. Further research of high scientific and methodologic quality is necessary to improve understanding of how LWSS hemodynamics relate to bAVM formation, rupture, and treatment.",
keywords = "Brain arteriovenous malformation, Cerebral arteries, Hemodynamics, Shear stress",
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Laminar wall shear stress in brain arteriovenous malformations : systematic review of literature. / Lo Presti, Anna; Rogers, Jeffrey M.; Stoodley, Marcus A.; Assaad, Nazih N. A.; Simons, Mary; Sen, Itsu; Morgan, Michael Kerin.

In: World Neurosurgery, Vol. 128, 01.08.2019, p. e760-e767.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Laminar wall shear stress in brain arteriovenous malformations

T2 - World Neurosurgery

AU - Lo Presti,Anna

AU - Rogers,Jeffrey M.

AU - Stoodley,Marcus A.

AU - Assaad,Nazih N. A.

AU - Simons,Mary

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AU - Morgan,Michael Kerin

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N2 - Background: Laminar wall sheer stress (LWSS) modulates inflammatory activity of the endothelium and may be a contributing factor in many cerebrovascular pathologies. There is a lack of consensus whether significant differences in LWSS exist between feeding vessels in brain arteriovenous malformation (bAVM) and healthy vessels. A systematic review of LWSS research in bAVM was undertaken, including the methods used and the assumptions made in determining LWSS. Methods: Ovid MEDLINE, EMBASE, and Scopus electronic databases were systematically searched from inception for articles calculating LWSS in bAVM cases. LWSS values were extracted for comparison between ipsilateral bAVM feeding arteries and healthy contralateral vessels or healthy normative data. Results: Three retrospective cohort studies were identified, reporting on 42 adult and pediatric bAVM cases. Mean LWSS (mLWSS) in healthy vessels (contralateral vessels or normative controls) typically ranged from 1.2–2.7 Pa, while mLWSS values in untreated bAVM feeding arteries typically ranged from 1.6–3.6 Pa. All studies had mixed cohorts of ruptured and unruptured cases, obscuring the relationship between LWSS and bAVM history. Conclusions: mLWSS values in healthy arteries and bAVM feeding vessels tend to be low and overlapping. Further research of high scientific and methodologic quality is necessary to improve understanding of how LWSS hemodynamics relate to bAVM formation, rupture, and treatment.

AB - Background: Laminar wall sheer stress (LWSS) modulates inflammatory activity of the endothelium and may be a contributing factor in many cerebrovascular pathologies. There is a lack of consensus whether significant differences in LWSS exist between feeding vessels in brain arteriovenous malformation (bAVM) and healthy vessels. A systematic review of LWSS research in bAVM was undertaken, including the methods used and the assumptions made in determining LWSS. Methods: Ovid MEDLINE, EMBASE, and Scopus electronic databases were systematically searched from inception for articles calculating LWSS in bAVM cases. LWSS values were extracted for comparison between ipsilateral bAVM feeding arteries and healthy contralateral vessels or healthy normative data. Results: Three retrospective cohort studies were identified, reporting on 42 adult and pediatric bAVM cases. Mean LWSS (mLWSS) in healthy vessels (contralateral vessels or normative controls) typically ranged from 1.2–2.7 Pa, while mLWSS values in untreated bAVM feeding arteries typically ranged from 1.6–3.6 Pa. All studies had mixed cohorts of ruptured and unruptured cases, obscuring the relationship between LWSS and bAVM history. Conclusions: mLWSS values in healthy arteries and bAVM feeding vessels tend to be low and overlapping. Further research of high scientific and methodologic quality is necessary to improve understanding of how LWSS hemodynamics relate to bAVM formation, rupture, and treatment.

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SN - 1878-8750

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