Large pore mesoporous silica induced weight loss in obese mice

Natalia Kupferschmidt, Robert I. Csikasz, Lluís Ballell, Tore Bengtsson, Alfonso E. Garcia-Bennett*

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: There is a need for medical treatments to curb the rising rate of obesity. Weight reduction is correlated with a decrease in associated risk factors and cholesterol levels in humans. Amorphous silica particles have been found to exert a hypocholesterolemic effect in humans, making them popular dietary additives. Aim: To investigate the effect of mesoporous silica, which possess sharp pore size distributions, on: weight loss, cholesterol, triglycerides and glucose blood levels in obese mice. Materials & methods: Mesoporous silicas with differing pore size were mixed in the high-fat diet of obese mice. Results: Animals receiving large pore mesoporous silica with a high-fat diet show a significant reduction in body weight and fat composition, with no observable negative effects. Conclusion: Pore size is an important parameter for reduction of body weight and body fat composition by mesoporous silica, demonstrating promising signs for the treatment of obesity.

Original languageEnglish
Pages (from-to)1353-1362
Number of pages10
JournalNanomedicine
Volume9
Issue number9
DOIs
Publication statusPublished - 1 Jul 2014
Externally publishedYes

Keywords

  • body fat
  • body weight
  • cholesterol
  • high-fat diet
  • mesoporous silica
  • obesity

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  • Cite this

    Kupferschmidt, N., Csikasz, R. I., Ballell, L., Bengtsson, T., & Garcia-Bennett, A. E. (2014). Large pore mesoporous silica induced weight loss in obese mice. Nanomedicine, 9(9), 1353-1362. https://doi.org/10.2217/nnm.13.138