Large vessel sealing with the argon laser

Rodney A. White*, George Kopchok, Carlos Donayre, Richard Lyons, Geoffrey White, Stanley R. Klein, Damon Pizzurro, R. Patrick Abergel, Richard M. Dwyer, Jouni Uitto

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    41 Citations (Scopus)


    This study compared the histology, biochemistry, and tensile strength of laser‐welded and sutured canine venotomies, arteriotomies, and arteriovenous fistulas. Twelve animals had bilateral femoral vessels studied, with one repair (control) closed with interrupted 6‐0 polypropylene sutures, and the contralateral repair (experimental) welded with the argon laser. Specimens were examined at weekly intervals from 1 to 4 weeks (four animals for each type of repair), and were evaluated histologically by hematoxylin and eosin, elastin, and trichrome stains; biochemically by the formation of [3H]hydroxyproline as an index of collagen synthesis; and mechanically by tensile strength determinations. At removal, all experimental closures were patent without hematomas, aneurysms, or luminal dilatation. Histologic and biochemical examination and tensile strength determinations suggest that laser welding may be an alternative to sutures for repair of large‐diameter venotomies, arteriotomies, and arteriovenous fistulas, as healing is comparable to that seen with suture repairs up to 4 weeks postoperatively.

    Original languageEnglish
    Pages (from-to)229-235
    Number of pages7
    JournalLasers in Surgery and Medicine
    Issue number3
    Publication statusPublished - 1987


    • arteriotomy
    • arteriovenous fistula
    • histology
    • tensile strength
    • tissue welding
    • venotomy


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