Laser-activated adhesive films for sutureless median nerve anastomosis

Mathew Barton, John W. Morley, Marcus A. Stoodley, Kheng Seong Ng, Sabine C. Piller, Hong Duong, Damia Mawad, David A. Mahns, Antonio Lauto*

*Corresponding author for this work

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    A novel chitosan adhesive film that incorporates the dye 'Rose Bengal' (RB) was used in conjunction with a green laser to repair transected rat median nerves in vivo. Histology and electrophysiological recording assessed the impact of the laser-adhesive technique on nerves. One week post-operatively, the sham-control group (laser-adhesive technique applied on un-transected nerves) conserved the average number and size of myelinated fibres in comparison to its contralateral side and electrophysiological recordings demonstrated no significant difference with un-operated nerves. Twelve weeks after the laser-adhesive anastomoses, nerves were in continuity with regenerated axons that crossed the anastomotic site.

    Original languageEnglish
    Pages (from-to)938-949
    Number of pages12
    JournalJournal of Biophotonics
    Volume6
    Issue number11-12
    DOIs
    Publication statusPublished - Dec 2013

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