Late-onset depression with mild cognitive deficits: Electrophysiological evidences for a preclinical dementia syndrome

Stefanie Brassen*, Dieter F. Braus, Wolfgang Weber-Fahr, Heike Tost, Steffen Moritz, Georg Adler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Mild cognitive impairment (MCI) is present in up to 60% of patients with late-onset depression and constitutes a major diagnostic problem in geriatric psychiatry. Searching for sensitive markers for the detection of early brain changes suggestive of dementia, we compared this depressive risk population with mildly to moderately demented patients and cognitively unimpaired depressed patients using EEG power and coherence. We found a considerable similarity between Alzheimer's disease patients and cognitively impaired depressed patients regarding the cognitive profile and EEG pattern. Changes in EEG power and coherence at frontotemporal leads in depressive patients with MCI thereby allowed discrimination from cognitively unimpaired patients with a sensitivity of 88% and a specifity of 81%.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalDementia and Geriatric Cognitive Disorders
Volume18
Issue number3-4
DOIs
Publication statusPublished - 2004
Externally publishedYes

Keywords

  • Coherence
  • Electroencephalography
  • Late-onset depression
  • Mild cognitive impairment

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