Lesion eccentricity and fractional flow reserve and coronary flow reserve in coronary arteries

Ashkan Javadzadegan, Andy S. C. Yong, Leonard Kritharides, Masud Behnia

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


Fractional flow reserve has shown to be a gold standard in assessment of functional significance of coronary artery stenosis. Lesion eccentricity is an important geometric parameter which may affect the translational hemodynamics. Three dimensional quantitative coronary angiography (3D-QCA) was used to reconstruct the proximal or mid left anterior descending artery of 56 patients. The fractional flow reserve (FFR) was measured using pressure–temperature sensor guidewire and the effects of lesion eccentricity (EI) was investigated on the correlation between FFR diameter stenosis (DS), area stenosis (AS), minimum lumen diameter (MLD) and minimum lumen area (MLA). A linear regression analysis showed a non-significant correlation between FFR and DS, AS, MLD and MLA. In order to improve the correlations, a receiver operating characteristic (ROC) curve analysis was used to identify the best cut-off value of eccentricity to predict FFR ≤ 0.75. It was found that for lesions whose eccentricity is above the cut-off, the correlations are significant; however, the correlations are weak for lesions with eccentricity below the cut-off.
Original languageEnglish
Title of host publicationAdvances in bio-mechanical systems and materials
EditorsAndreas Öchsner, Holm Altenbach
Place of PublicationSwitzerland
PublisherSpringer, Springer Nature
Number of pages6
ISBN (Print)9783319004792
Publication statusPublished - 2013
Externally publishedYes

Publication series

NameAdvanced structured materials
ISSN (Print)1869-8441


  • coronary artery
  • eccentricity
  • fractional flow reserve
  • stenosis


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