Abstract
Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application, and exquisite temporal and spatial control. Great progress is achieved in the development of novel light-driven drug delivery strategies with both breadth and depth. Light-controlled drug delivery platforms can be generally categorized into three groups: photochemical, photothermal, and photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, metal sulfides and oxides, metal–organic frameworks, carbon nanomaterials, upconversion nanoparticles, semiconductor nanoparticles, stimuli-responsive micelles, polymer- and liposome-based nanoparticles are applied for light-stimulated drug delivery. In view of the increasing interest in on-demand targeted drug delivery, the development of light-responsive systems with a focus on recent advances, key limitations, and future directions is reviewed.
| Original language | English |
|---|---|
| Article number | 2005029 |
| Pages (from-to) | 1-28 |
| Number of pages | 28 |
| Journal | Advanced Functional Materials |
| Volume | 30 |
| Issue number | 49 |
| Early online date | 9 Sept 2020 |
| DOIs | |
| Publication status | Published - 1 Dec 2020 |
| Externally published | Yes |
Keywords
- drug delivery
- light
- photochemical
- photoisomerization
- photothermal