Linear dichroism of biomolecules: Which way is up?

Timothy R. Dafforn, Alison Rodger

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)


Understanding the organization of molecules in naturally occurring ordered arrays (e.g. membranes, protein fibres and DNA strands) is of great importance to understanding biological function. Unfortunately, few biophysical techniques provide detailed structural information on these non-crystalline systems. UV, visible and IR linear dichroism have the potential to provide such information. Recent advances in technology and simulations allow this potential to be fulfilled, and can now provide a detailed understanding of the molecular mechanisms of such fundamental biological processes as amyloid fibre formation and membrane protein folding.

Original languageEnglish
Pages (from-to)541-546
Number of pages6
JournalCurrent Opinion in Structural Biology
Issue number5
Publication statusPublished - Oct 2004
Externally publishedYes


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