Lipase-catalyzed synthesis of hyperbranched polyester improved by autocatalytic prepolymerization process

Liuen Liang, Junyuan Long, Guangji Li

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This work developed a facile and environmentally friendly route for lipase-catalyzed synthesis of a hyperbranched polyester by introducing an autocatalytic prepolymerization of comonomers. Trimethylolpropane, 1,8-octanediol, and adipic acid as comonomers for synthesizing the hyperbranched polyester were first prepolymerized via the automatic catalytic effect of the reactants themselves to obtain an appropriate reaction substrate for further lipase-catalyzed polymerization, where immobilized lipase Novozym 435 was used as a biocatalyst. The acidity and fluidity of optimized oligomers after the autocatalytic prepolymerization provide a benign reaction substrate for the retention of enzymatic activity in the subsequent lipase-catalyzed esterification, which is crucial for the enzymatic polymerization. The optimum reaction temperature and reaction time for prepolymerization were determined to be 120 °C and 150 min. The molecular weight (Mw) of the prepared polyester was approximately 26,300 g/mol. Quantitative analysis of 1H-NMR and inverse-gated 13C-NMR spectra confirmed the hyperbranched structure of the resulting polyester with a branching degree of 31.3%.

LanguageEnglish
Article number47221
Pages1-8
Number of pages8
JournalJournal of Applied Polymer Science
Volume136
Issue number12
Early online date30 Oct 2018
DOIs
Publication statusPublished - 20 Mar 2019

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Polyesters
Lipases
Lipase
Polymerization
Nuclear magnetic resonance
Biocatalysts
Fluidity
Esterification
Substrates
Oligomers
Acidity
Molecular weight
Acids
Enzymes
Chemical analysis
Temperature

Cite this

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title = "Lipase-catalyzed synthesis of hyperbranched polyester improved by autocatalytic prepolymerization process",
abstract = "This work developed a facile and environmentally friendly route for lipase-catalyzed synthesis of a hyperbranched polyester by introducing an autocatalytic prepolymerization of comonomers. Trimethylolpropane, 1,8-octanediol, and adipic acid as comonomers for synthesizing the hyperbranched polyester were first prepolymerized via the automatic catalytic effect of the reactants themselves to obtain an appropriate reaction substrate for further lipase-catalyzed polymerization, where immobilized lipase Novozym 435 was used as a biocatalyst. The acidity and fluidity of optimized oligomers after the autocatalytic prepolymerization provide a benign reaction substrate for the retention of enzymatic activity in the subsequent lipase-catalyzed esterification, which is crucial for the enzymatic polymerization. The optimum reaction temperature and reaction time for prepolymerization were determined to be 120 °C and 150 min. The molecular weight (Mw) of the prepared polyester was approximately 26,300 g/mol. Quantitative analysis of 1H-NMR and inverse-gated 13C-NMR spectra confirmed the hyperbranched structure of the resulting polyester with a branching degree of 31.3{\%}.",
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Lipase-catalyzed synthesis of hyperbranched polyester improved by autocatalytic prepolymerization process. / Liang, Liuen; Long, Junyuan; Li, Guangji.

In: Journal of Applied Polymer Science, Vol. 136, No. 12, 47221, 20.03.2019, p. 1-8.

Research output: Contribution to journalArticleResearchpeer-review

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