Local anaesthetics for acute reversible blockade of the sympathetic baroreceptor reflex in the rat

Melissa M J Farnham, Paul M. Pilowsky*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    Sinoaortic denervation is a common method used in the investigation of function in the cardiovascular system. In the rat, this is usually accomplished by transection of the carotid sinus and aortic depressor nerves, which is permanent. We propose a novel, and simple method for acute baroreceptor denervation in the rat in which the region around the carotid sinuses is superfused with local anaesthetic agents. We demonstrate that complete baroreceptor denervation can be achieved for longer (bupivacaine, 30-60 min) or shorter (lignocaine, 10-30 min) periods, without harming the physiological state of the rat. Crown

    Original languageEnglish
    Pages (from-to)58-62
    Number of pages5
    JournalJournal of Neuroscience Methods
    Volume179
    Issue number1
    DOIs
    Publication statusPublished - 30 Apr 2009

    Keywords

    • Sinoaortic denervation
    • Bupivacaine
    • Lignocaine
    • Carotid sinus

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