TY - JOUR
T1 - Local anaesthetics for acute reversible blockade of the sympathetic baroreceptor reflex in the rat
AU - Farnham, Melissa M J
AU - Pilowsky, Paul M.
PY - 2009/4/30
Y1 - 2009/4/30
N2 - Sinoaortic denervation is a common method used in the investigation of function in the cardiovascular system. In the rat, this is usually accomplished by transection of the carotid sinus and aortic depressor nerves, which is permanent. We propose a novel, and simple method for acute baroreceptor denervation in the rat in which the region around the carotid sinuses is superfused with local anaesthetic agents. We demonstrate that complete baroreceptor denervation can be achieved for longer (bupivacaine, 30-60 min) or shorter (lignocaine, 10-30 min) periods, without harming the physiological state of the rat. Crown
AB - Sinoaortic denervation is a common method used in the investigation of function in the cardiovascular system. In the rat, this is usually accomplished by transection of the carotid sinus and aortic depressor nerves, which is permanent. We propose a novel, and simple method for acute baroreceptor denervation in the rat in which the region around the carotid sinuses is superfused with local anaesthetic agents. We demonstrate that complete baroreceptor denervation can be achieved for longer (bupivacaine, 30-60 min) or shorter (lignocaine, 10-30 min) periods, without harming the physiological state of the rat. Crown
KW - Sinoaortic denervation
KW - Bupivacaine
KW - Lignocaine
KW - Carotid sinus
UR - http://www.scopus.com/inward/record.url?scp=61649091765&partnerID=8YFLogxK
U2 - 10.1016/j.jneumeth.2009.01.012
DO - 10.1016/j.jneumeth.2009.01.012
M3 - Article
C2 - 19428512
AN - SCOPUS:61649091765
SN - 0165-0270
VL - 179
SP - 58
EP - 62
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
IS - 1
ER -