Local delivery of corticosteroids in clinical ophthalmology: a review

Adrian T. Fung; Tuan Tran; Lyndell L. Lim; Chameen Samarawickrama; Jennifer Arnold; Mark Gillies; Caroline Catt; Logan Mitchell; Andrew Symons; Robert Buttery; Lisa Cottee; Krishna Tumuluri; Paul Beaumont

doi:10.1111/ceo.13702

Local delivery of corticosteroids in clinical ophthalmology: a review

Adrian T. Fung, Tuan Tran, Lyndell L. Lim, Chameen Samarawickrama, Jennifer Arnold, Mark Gillies, Caroline Catt, Logan Mitchell, Andrew Symons, Robert Buttery, Lisa Cottee, Krishna Tumuluri, Paul Beaumont

Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

33 Downloads (Pure)

Abstract

Locally administered steroids have a long history in ophthalmology for the treatment of inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids whilst posterior segment conditions generally require periocular, intravitreal or systemic administration for penetration. Over recent decades, the clinical applications of periocular steroid delivery have expanded to a wide range of conditions including macular oedema from retino-vascular conditions. Formulations have been developed with the aim to provide practical, targeted, longer-term and more efficacious therapy whilst minimizing side effects. Herein, we provide a comprehensive overview of the types of periocular steroid delivery, their clinical applications in ophthalmology and their side effects.

Original language	English
Pages (from-to)	366-401
Number of pages	36
Journal	Clinical and Experimental Ophthalmology
Volume	48
Issue number	3
Early online date	20 Dec 2019
DOIs	https://doi.org/10.1111/ceo.13702
Publication status	Published - Apr 2020

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Fluocinolone acetonide
corticosteroid
dexamethasone
prednisolone acetate
triamcinolone acetonide

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10.1111/ceo.13702

Publisher version (open access)Final published version, 6 MBLicence: CC BY

Cite this

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title = "Local delivery of corticosteroids in clinical ophthalmology: a review",

abstract = "Locally administered steroids have a long history in ophthalmology for the treatment of inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids whilst posterior segment conditions generally require periocular, intravitreal or systemic administration for penetration. Over recent decades, the clinical applications of periocular steroid delivery have expanded to a wide range of conditions including macular oedema from retino-vascular conditions. Formulations have been developed with the aim to provide practical, targeted, longer-term and more efficacious therapy whilst minimizing side effects. Herein, we provide a comprehensive overview of the types of periocular steroid delivery, their clinical applications in ophthalmology and their side effects.",

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doi = "10.1111/ceo.13702",

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AU - Tran, Tuan

AU - Lim, Lyndell L.

AU - Samarawickrama, Chameen

AU - Arnold, Jennifer

AU - Gillies, Mark

AU - Catt, Caroline

AU - Mitchell, Logan

AU - Symons, Andrew

AU - Buttery, Robert

AU - Cottee, Lisa

AU - Tumuluri, Krishna

AU - Beaumont, Paul

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PY - 2020/4

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AB - Locally administered steroids have a long history in ophthalmology for the treatment of inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids whilst posterior segment conditions generally require periocular, intravitreal or systemic administration for penetration. Over recent decades, the clinical applications of periocular steroid delivery have expanded to a wide range of conditions including macular oedema from retino-vascular conditions. Formulations have been developed with the aim to provide practical, targeted, longer-term and more efficacious therapy whilst minimizing side effects. Herein, we provide a comprehensive overview of the types of periocular steroid delivery, their clinical applications in ophthalmology and their side effects.

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KW - dexamethasone

KW - prednisolone acetate

KW - triamcinolone acetonide

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JF - Clinical and Experimental Ophthalmology

SN - 1442-6404

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ER -

Local delivery of corticosteroids in clinical ophthalmology: a review

Abstract

Bibliographical note

Keywords

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