Local delivery of corticosteroids in clinical ophthalmology: a review

Adrian T. Fung, Tuan Tran, Lyndell L. Lim, Chameen Samarawickrama, Jennifer Arnold, Mark Gillies, Caroline Catt, Logan Mitchell, Andrew Symons, Robert Buttery, Lisa Cottee, Krishna Tumuluri, Paul Beaumont

    Research output: Contribution to journalReview articlepeer-review

    14 Citations (Scopus)
    31 Downloads (Pure)

    Abstract

    Locally administered steroids have a long history in ophthalmology for the treatment of inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids whilst posterior segment conditions generally require periocular, intravitreal or systemic administration for penetration. Over recent decades, the clinical applications of periocular steroid delivery have expanded to a wide range of conditions including macular oedema from retino-vascular conditions. Formulations have been developed with the aim to provide practical, targeted, longer-term and more efficacious therapy whilst minimizing side effects. Herein, we provide a comprehensive overview of the types of periocular steroid delivery, their clinical applications in ophthalmology and their side effects.

    Original languageEnglish
    Pages (from-to)366-401
    Number of pages36
    JournalClinical and Experimental Ophthalmology
    Volume48
    Issue number3
    Early online date20 Dec 2019
    DOIs
    Publication statusPublished - Apr 2020

    Bibliographical note

    Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

    Keywords

    • Fluocinolone acetonide
    • corticosteroid
    • dexamethasone
    • prednisolone acetate
    • triamcinolone acetonide

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