Local dynamics of pharmaceutical powder fluidization using high speed long distance microscopy and particle image velocimetry

K. Elserfy, S. Cheng*, H. K. Chan, A. Kourmatzis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The local dynamics of fluidized pharmaceutical carrier powders in a turbulent channel flow was studied using particle image velocimetry (PIV) and High-speed, long-distance microscopy (HS-LDM). Four different lactose powders which have been used as a drug carrier in dry powder inhalers were used in this study. These powders have median powder particle diameters ranging between 61 and 121 µm. Air flow velocities ranging between 13.3 m/s and 66.7 m/s were examined. In addition, the effect of grid blockage ratio (ranging from ~25% to ~40% of the area of channel cross-section) was also investigated. Results show that the high-speed, long-distance microscopy (HS-LDM) technique was able to capture the mean velocity of the particles, and the results corresponded well with the PIV measurements. Results from the high-speed, long-distance microscopy (HS-LDM) method also demonstrate that the span of particle velocity closely follows that of the particle size distribution both for cohesive and non-cohesive powders. This study contributes towards an improved understanding of pharmaceutical carrier dynamics in turbulent channel flows and demonstrates how advanced image processing can be used to capture local particle dynamics.

Original languageEnglish
Article number110367
Pages (from-to)1-15
Number of pages15
JournalExperimental Thermal and Fluid Science
Volume124
DOIs
Publication statusPublished - 1 Jun 2021

Keywords

  • Two-phase flow
  • Dry powder inhalers
  • Lactose carriers
  • Pharmaceutical carriers
  • Advanced imaging techniques

Fingerprint Dive into the research topics of 'Local dynamics of pharmaceutical powder fluidization using high speed long distance microscopy and particle image velocimetry'. Together they form a unique fingerprint.

Cite this