Local IgE production in nonatopic nasal polyposis

Patrick Sheahan, Chadwick N. Ahn, Richard J. Harvey, Sarah K. Wise, Ryan M. Mulligan, Deanne M R Lathers, Rodney J. Schlosser

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Introduction: Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents an eosinophilic T-helper 2 inflammatory response. Local production of IgE within nasal polyps (NPs) has been demonstrated, suggesting a role for local IgE in the pathogenesis of NP in atopic CRS patients. We hypothesized that local IgE specific to inhalant allergens may also play a role in the genesis of NP in nonatopic CRS patients. Methods: Sinus and inferior turbinate tissue was obtained from nonatopic CRSwNP patients (n = 7), chronic rhinosinusitis without nasal polyps (CRSsNP) patients (n = 15), and healthy controls (n = 9) at the time of surgery. ImmunoCAP analysis (Phadia AB, Portage, MI) for 14 common inhalant antigens was performed on tissue homogenates to determine the antigen-specific response. Results: Total IgE levels did not differ in sinus or turbinate tissue between CRSwNP, CRSsNP, or control patients. CRSwNP sinus tissue had higher levels of specific IgE for cockroach and plantain (p = .03) than other groups and elevated Alternaria IgE levels when compared with CRSsNP sinus tissue (p < .05). No significant differences were found for any of the other antigen-specific IgE levels. Fifty-seven percent of CRSwNP polyps demonstrated a polyclonal IgE response, whereas the other 43% had no demonstrable antigen-specific IgE. In contrast, only 17% of CRSsNP patients demonstrated a polyclonal response within sinus tissue, whereas 67% had no detectable antigen-specific IgE. There was no significant difference in levels of IgE in inferior turbinate tissue between the groups (p > .05). Conclusions: Localized mucosal IgE specific to common inhalant allergens appears to play a role in a subset of CRSwNP patients without evidence of systemic atopy.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalJournal of Otolaryngology - Head and Neck Surgery
Volume39
Issue number1
DOIs
Publication statusPublished - 1 Feb 2010
Externally publishedYes

Keywords

  • Chronic rhinosinusitis
  • IgE
  • Local production
  • Nasal polyps
  • Specific IgE

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