Long-term canine duct-occluded segmental pancreatic autografts

Endocrine function

Peter Williamson*, Stephen A. Deane, Henrik Ekberg, Wayne J. Hawthorne, John F W Garvey, Graeme J. Stewart, Creswell J. Eastman, J. Miles Little

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This study examines the endocrine function of duct-obliterated canine segmental autografts for periods up to 5 years posttransplant. Overall the response profile of autografted animals was subnormal. After intravenous glucose tolerance tests K-values in transplanted animals (2.8 ± 0.9%/min) were significantly lower than normal (4.6 ± 1.2% min, p < 0.001). After oral glucose stimulation, blood glucose in the autografted dogs reached a mean peak of 10.6 ± 2.8 mmol/L whereas in normal dogs the peak value was 6.0 ± 1.0 mmol/L (p < 0.002). The mean insulin response in autografted dogs showed lower insulin concentrations in the early stages of the test, whereas insulin secretion after glucagon stimulation was significantly reduced in autografted dogs. Intravenous glucose tolerance tests were analyzed by calculating K value or measuring a single blood glucose concentration 40 min after glucose injection. This value had a high correlation with the K value (r = 0.967). No progressive deterioration of graft function up to 5 years was found. Glycosylated hemoglobin levels were measured in autografted (646 ± 59 pmol/mg) and normal dogs (620 ± 85 pmol/mg) and no significant difference was found. In conclusion, duct-occluded segmental pancreatic autografts were shown to have a reduced functional capacity but there was no deterioration of function up to 5 years after duct-occlusion and grafting. The degree of metabolic control may be sufficient to prevent diabetic complications.

Original languageEnglish
Pages (from-to)646-652
Number of pages7
JournalPancreas
Volume3
Issue number6
Publication statusPublished - 1988
Externally publishedYes

Keywords

  • Autografts
  • Duct occlusion
  • Endocrine function
  • Pancreas
  • Pancreas

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