Longitudinal changes in central corneal thickness in glaucoma subjects and relationship to medications

Deepa Viswanathan, Stuart Graham, Ivan Goldberg

    Research output: Contribution to journalMeeting abstractpeer-review


    Purpose: To study long term changes in central corneal thickness (CCT) and the effect of topical antiglaucoma medications. Methods: 184 patients (mean follow up of 6.92 ± 1.67 years) from a Glaucoma clinic who were being treated with topical antiglaucoma medications for at least 3 years, and 94 glaucoma suspects (mean follow up of 6.58 ± 1.93 years) who were not on any treatment were included in the study. Their demographic data, visual acuity, spherical equivalent, CCT and Intraocular pressure (IOP) were collected both at the initial diagnosis of glaucoma and at the present visit. For analysis, only the right eyes of patients and controls were taken. Results: There was a significant reduction in CCT (p < 0.0001) in the treated group whereas there was no significant change in the control group (p > 0.05). The mean reduction in CCT was 12.03 ± 12.72 μm in treated eyes and 1.20 ± 9.18 μm in controls. Amongst the treated group, the reduction in CCT was significant (p < 0.0001) in those treated with either Prostaglandins or a combination of Prostaglandins and Beta-blockers, while there was no significant reduction in eyes treated only with Betablockers(p > 0.05) when compared to control eyes. Conclusions: There is a mild but significant reduction in CCT observed in glaucoma patients, and this may be increased in those on topical prostaglandins. Serial CCT measurements are recommended in glaucoma patients.
    Original languageEnglish
    Article number1809
    Pages (from-to)46-46
    Number of pages1
    JournalClinical and Experimental Ophthalmology
    Issue numberS1
    Publication statusPublished - Nov 2011


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