Longitudinal changes in sulcal morphology associated with late-life aging and MCI

Tao Liu, Perminder S. Sachdev, Darren M. Lipnicki, Jiyang Jiang, Yue Cui, Nicole A. Kochan, Simone Reppermund, Julian N. Trollor, Henry Brodaty, Wei Wen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


The present study investigated changes in sulcal morphology associated with late-life aging and mild cognitive impairment (MCI). Participants were 219 community-dwelling 70-90. year-olds from the Sydney Memory and Ageing Study; all had MRI scans and were classified as having normal cognition (NC) or MCI at each of waves 1 and 2, two years apart. Automated methods were used to calculate a global sulcal index (g-SI), widths of five prominent sulci, and regional cortical thickness. There were significant longitudinal declines in g-SI and increases in sulcal width among the entire sample, but the rate of change differed among cognitive subgroups. Participants with MCI at both waves (persisting MCI) showed accelerated sulcal widening, particularly for the superior frontal and superior temporal sulci. The sulcal morphology of participants who reverted from MCI to NC was more consistent with stable NC than persisting MCI. Overall cortical thickness decreased between waves similarly across the subgroups. While changes in sulcal morphology are characteristic of normal late-life aging, they are accelerated in individuals with MCI (in contrast to changes in cortical thickness). Sulcal measures also differentiate between persistent MCI and MCI that reverts to NC, and may thus help in predicting the prognosis of MCI patients.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
Publication statusPublished - 1 Jul 2013
Externally publishedYes


  • Aging
  • Cortical sulci
  • Magnetic resonance imaging
  • Mild cognitive impairment
  • Sulcal width


Dive into the research topics of 'Longitudinal changes in sulcal morphology associated with late-life aging and MCI'. Together they form a unique fingerprint.

Cite this