Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders

Marius Ringelstein; Jens Harmel; Hanna Zimmermann; Alexander U. Brandt; Friedemann Paul; Axel Haarmann; Mathias Buttmann; Martin W. Hummert; Corinna Trebst; Christoph Schroeder; Ilya Ayzenberg; Ingo Kleiter; Kerstin Hellwig; Joachim Havla; Tania Kumpfel; Sven Jarius; Brigitte Wildemann; Paulus Rommer; Martin S. Weber; Hannah Pellkofer; Luise Ropke; Christian Geis; Nele Retzlaff; Uwe Zetti; Michael Deppe; Luisa Klotz; Kim Young; Jan-Patrick Stellmann; Matthias Kaste; Pawel Kermer; Wael Marouf; Florian Lauda; Hayrettin Tumani; Jonas Graf; Alexander Klistorner; Hans-Peter Hartung; Orhan Aktas; Philipp Albrecht; Neuromyelitis Optica Study Group (NEMOS)

doi:10.1212/WNL.0000000000008684

Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders

Marius Ringelstein, Jens Harmel, Hanna Zimmermann, Alexander U. Brandt, Friedemann Paul, Axel Haarmann, Mathias Buttmann, Martin W. Hummert, Corinna Trebst, Christoph Schroeder, Ilya Ayzenberg, Ingo Kleiter, Kerstin Hellwig, Joachim Havla, Tania Kumpfel, Sven Jarius, Brigitte Wildemann, Paulus Rommer, Martin S. Weber, Hannah PellkoferLuise Ropke, Christian Geis, Nele Retzlaff, Uwe Zetti, Michael Deppe, Luisa Klotz, Kim Young, Jan-Patrick Stellmann, Matthias Kaste, Pawel Kermer, Wael Marouf, Florian Lauda, Hayrettin Tumani, Jonas Graf, Alexander Klistorner, Hans-Peter Hartung, Orhan Aktas, Philipp Albrecht, Neuromyelitis Optica Study Group (NEMOS)

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Objective: To investigate if patients with neuromyelitis optica spectrum disorder (NMOSD) develop subclinical visual pathway impairment independent of acute attacks. Methods: A total of 548 longitudinally assessed full-field visual evoked potentials (VEP) of 167 patients with NMOSD from 16 centers were retrospectively evaluated for changes of P100 latencies and P100-N140 amplitudes. Rates of change in latencies (RCL) and amplitudes (RCA) over time were analyzed for each individual eye using linear regression and compared using generalized estimating equation models. Results: The rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951 ms/y (n = 101 eyes; SD = 6.274; p = 0.012) for the P100 latencies and -2.149 µV/y (n = 64 eyes; SD = 5.013; p = 0.005) for the P100-N140 amplitudes. For minimal VEP intervals of ≥12 months, the RCL was +1.768 ms/y (n = 59 eyes; SD = 4.558; p = 0.024) and the RCA was -0.527 µV/y (n = 44 eyes; SD = 2.123; p = 0.111). The history of a previous ON >6 months before baseline VEP had no influence on RCL and RCA. ONs during the observational period led to mean RCL and RCA of +11.689 ms/y (n = 16 eyes; SD = 17.593; p = 0.003) and -1.238 µV/y (n = 11 eyes; SD = 3.708; p = 0.308), respectively. Conclusion: This first longitudinal VEP study of patients with NMOSD provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpret the clinical relevance.

Original language	English
Pages (from-to)	e407-e418
Number of pages	12
Journal	Neurology
Volume	94
Issue number	4
DOIs	https://doi.org/10.1212/WNL.0000000000008684
Publication status	Published - 28 Jan 2020

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Ringelstein, M., Harmel, J., Zimmermann, H., Brandt, A. U., Paul, F., Haarmann, A., Buttmann, M., Hummert, M. W., Trebst, C., Schroeder, C., Ayzenberg, I., Kleiter, I., Hellwig, K., Havla, J., Kumpfel, T., Jarius, S., Wildemann, B., Rommer, P., Weber, M. S., ... Neuromyelitis Optica Study Group (NEMOS) (2020). Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders. Neurology, 94(4), e407-e418. https://doi.org/10.1212/WNL.0000000000008684

@article{e00ea3fa4553480997675c178e08020c,

title = "Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders",

abstract = "Objective: To investigate if patients with neuromyelitis optica spectrum disorder (NMOSD) develop subclinical visual pathway impairment independent of acute attacks. Methods: A total of 548 longitudinally assessed full-field visual evoked potentials (VEP) of 167 patients with NMOSD from 16 centers were retrospectively evaluated for changes of P100 latencies and P100-N140 amplitudes. Rates of change in latencies (RCL) and amplitudes (RCA) over time were analyzed for each individual eye using linear regression and compared using generalized estimating equation models. Results: The rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951 ms/y (n = 101 eyes; SD = 6.274; p = 0.012) for the P100 latencies and -2.149 µV/y (n = 64 eyes; SD = 5.013; p = 0.005) for the P100-N140 amplitudes. For minimal VEP intervals of ≥12 months, the RCL was +1.768 ms/y (n = 59 eyes; SD = 4.558; p = 0.024) and the RCA was -0.527 µV/y (n = 44 eyes; SD = 2.123; p = 0.111). The history of a previous ON >6 months before baseline VEP had no influence on RCL and RCA. ONs during the observational period led to mean RCL and RCA of +11.689 ms/y (n = 16 eyes; SD = 17.593; p = 0.003) and -1.238 µV/y (n = 11 eyes; SD = 3.708; p = 0.308), respectively. Conclusion: This first longitudinal VEP study of patients with NMOSD provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpret the clinical relevance.",

author = "Marius Ringelstein and Jens Harmel and Hanna Zimmermann and Brandt, {Alexander U.} and Friedemann Paul and Axel Haarmann and Mathias Buttmann and Hummert, {Martin W.} and Corinna Trebst and Christoph Schroeder and Ilya Ayzenberg and Ingo Kleiter and Kerstin Hellwig and Joachim Havla and Tania Kumpfel and Sven Jarius and Brigitte Wildemann and Paulus Rommer and Weber, {Martin S.} and Hannah Pellkofer and Luise Ropke and Christian Geis and Nele Retzlaff and Uwe Zetti and Michael Deppe and Luisa Klotz and Kim Young and Jan-Patrick Stellmann and Matthias Kaste and Pawel Kermer and Wael Marouf and Florian Lauda and Hayrettin Tumani and Jonas Graf and Alexander Klistorner and Hans-Peter Hartung and Orhan Aktas and Philipp Albrecht and {Neuromyelitis Optica Study Group (NEMOS)}",

year = "2020",

month = jan,

day = "28",

doi = "10.1212/WNL.0000000000008684",

language = "English",

volume = "94",

pages = "e407--e418",

journal = "Neurology",

issn = "0028-3878",

publisher = "AAN Enterprises",

number = "4",

}

Ringelstein, M, Harmel, J, Zimmermann, H, Brandt, AU, Paul, F, Haarmann, A, Buttmann, M, Hummert, MW, Trebst, C, Schroeder, C, Ayzenberg, I, Kleiter, I, Hellwig, K, Havla, J, Kumpfel, T, Jarius, S, Wildemann, B, Rommer, P, Weber, MS, Pellkofer, H, Ropke, L, Geis, C, Retzlaff, N, Zetti, U, Deppe, M, Klotz, L, Young, K, Stellmann, J-P, Kaste, M, Kermer, P, Marouf, W, Lauda, F, Tumani, H, Graf, J, Klistorner, A, Hartung, H-P, Aktas, O, Albrecht, P & Neuromyelitis Optica Study Group (NEMOS) 2020, 'Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders', Neurology, vol. 94, no. 4, pp. e407-e418. https://doi.org/10.1212/WNL.0000000000008684

TY - JOUR

T1 - Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders

AU - Ringelstein, Marius

AU - Harmel, Jens

AU - Zimmermann, Hanna

AU - Brandt, Alexander U.

AU - Paul, Friedemann

AU - Haarmann, Axel

AU - Buttmann, Mathias

AU - Hummert, Martin W.

AU - Trebst, Corinna

AU - Schroeder, Christoph

AU - Ayzenberg, Ilya

AU - Kleiter, Ingo

AU - Hellwig, Kerstin

AU - Havla, Joachim

AU - Kumpfel, Tania

AU - Jarius, Sven

AU - Wildemann, Brigitte

AU - Rommer, Paulus

AU - Weber, Martin S.

AU - Pellkofer, Hannah

AU - Ropke, Luise

AU - Geis, Christian

AU - Retzlaff, Nele

AU - Zetti, Uwe

AU - Deppe, Michael

AU - Klotz, Luisa

AU - Young, Kim

AU - Stellmann, Jan-Patrick

AU - Kaste, Matthias

AU - Kermer, Pawel

AU - Marouf, Wael

AU - Lauda, Florian

AU - Tumani, Hayrettin

AU - Graf, Jonas

AU - Klistorner, Alexander

AU - Hartung, Hans-Peter

AU - Aktas, Orhan

AU - Albrecht, Philipp

AU - Neuromyelitis Optica Study Group (NEMOS)

PY - 2020/1/28

Y1 - 2020/1/28

N2 - Objective: To investigate if patients with neuromyelitis optica spectrum disorder (NMOSD) develop subclinical visual pathway impairment independent of acute attacks. Methods: A total of 548 longitudinally assessed full-field visual evoked potentials (VEP) of 167 patients with NMOSD from 16 centers were retrospectively evaluated for changes of P100 latencies and P100-N140 amplitudes. Rates of change in latencies (RCL) and amplitudes (RCA) over time were analyzed for each individual eye using linear regression and compared using generalized estimating equation models. Results: The rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951 ms/y (n = 101 eyes; SD = 6.274; p = 0.012) for the P100 latencies and -2.149 µV/y (n = 64 eyes; SD = 5.013; p = 0.005) for the P100-N140 amplitudes. For minimal VEP intervals of ≥12 months, the RCL was +1.768 ms/y (n = 59 eyes; SD = 4.558; p = 0.024) and the RCA was -0.527 µV/y (n = 44 eyes; SD = 2.123; p = 0.111). The history of a previous ON >6 months before baseline VEP had no influence on RCL and RCA. ONs during the observational period led to mean RCL and RCA of +11.689 ms/y (n = 16 eyes; SD = 17.593; p = 0.003) and -1.238 µV/y (n = 11 eyes; SD = 3.708; p = 0.308), respectively. Conclusion: This first longitudinal VEP study of patients with NMOSD provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpret the clinical relevance.

AB - Objective: To investigate if patients with neuromyelitis optica spectrum disorder (NMOSD) develop subclinical visual pathway impairment independent of acute attacks. Methods: A total of 548 longitudinally assessed full-field visual evoked potentials (VEP) of 167 patients with NMOSD from 16 centers were retrospectively evaluated for changes of P100 latencies and P100-N140 amplitudes. Rates of change in latencies (RCL) and amplitudes (RCA) over time were analyzed for each individual eye using linear regression and compared using generalized estimating equation models. Results: The rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951 ms/y (n = 101 eyes; SD = 6.274; p = 0.012) for the P100 latencies and -2.149 µV/y (n = 64 eyes; SD = 5.013; p = 0.005) for the P100-N140 amplitudes. For minimal VEP intervals of ≥12 months, the RCL was +1.768 ms/y (n = 59 eyes; SD = 4.558; p = 0.024) and the RCA was -0.527 µV/y (n = 44 eyes; SD = 2.123; p = 0.111). The history of a previous ON >6 months before baseline VEP had no influence on RCL and RCA. ONs during the observational period led to mean RCL and RCA of +11.689 ms/y (n = 16 eyes; SD = 17.593; p = 0.003) and -1.238 µV/y (n = 11 eyes; SD = 3.708; p = 0.308), respectively. Conclusion: This first longitudinal VEP study of patients with NMOSD provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpret the clinical relevance.

UR - http://www.scopus.com/inward/record.url?scp=85078572159&partnerID=8YFLogxK

U2 - 10.1212/WNL.0000000000008684

DO - 10.1212/WNL.0000000000008684

M3 - Article

C2 - 31796527

SN - 0028-3878

VL - 94

SP - e407-e418

JO - Neurology

JF - Neurology

IS - 4

ER -

Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders

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