Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease

Ying Xia; Paul Maruff; Vincent Doré; Pierrick Bourgeat; Simon M. Laws; Christopher Fowler; Stephanie R. Rainey-Smith; Ralph N. Martins; Victor L. Villemagne; Christopher C. Rowe; Colin L. Masters; Elizabeth J. Coulson; Jurgen Fripp

doi:10.1016/j.neurobiolaging.2023.09.002

Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease

Ying Xia^*, Paul Maruff, Vincent Doré, Pierrick Bourgeat, Simon M. Laws, Christopher Fowler, Stephanie R. Rainey-Smith, Ralph N. Martins, Victor L. Villemagne, Christopher C. Rowe, Colin L. Masters, Elizabeth J. Coulson, Jurgen Fripp

^*Corresponding author for this work

Macquarie Medical School

Research output: Contribution to journal › Article › peer-review

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Abstract

Dysfunction of the cholinergic basal forebrain (BF) system and amyloid-β (Aβ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ−, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was much greater in the predominantly cholinergic subregion of Ch4p, whereas no difference was observed for the Ch1/Ch2 region. The findings support early and substantial vulnerability of the BF and further reveal distinctive degeneration of BF subregions during early AD.

Original language	English
Pages (from-to)	120-130
Number of pages	11
Journal	Neurobiology of Aging
Volume	132
DOIs	https://doi.org/10.1016/j.neurobiolaging.2023.09.002
Publication status	Published - Dec 2023

Bibliographical note

Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Alzheimer's disease
Amyloid-β
basal forebrain
longitudinal
magnetic resonance imaging

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10.1016/j.neurobiolaging.2023.09.002Licence: CC BY-NC

Publisher version (open access)Final published version, 5.67 MBLicence: CC BY-NC

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Xia, Y., Maruff, P., Doré, V., Bourgeat, P., Laws, S. M., Fowler, C., Rainey-Smith, S. R., Martins, R. N., Villemagne, V. L., Rowe, C. C., Masters, C. L., Coulson, E. J., & Fripp, J. (2023). Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease. Neurobiology of Aging, 132, 120-130. https://doi.org/10.1016/j.neurobiolaging.2023.09.002

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title = "Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease",

abstract = "Dysfunction of the cholinergic basal forebrain (BF) system and amyloid-β (Aβ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ−, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was much greater in the predominantly cholinergic subregion of Ch4p, whereas no difference was observed for the Ch1/Ch2 region. The findings support early and substantial vulnerability of the BF and further reveal distinctive degeneration of BF subregions during early AD.",

keywords = "Alzheimer's disease, Amyloid-β, basal forebrain, longitudinal, magnetic resonance imaging",

author = "Ying Xia and Paul Maruff and Vincent Dor{\'e} and Pierrick Bourgeat and Laws, \{Simon M.\} and Christopher Fowler and Rainey-Smith, \{Stephanie R.\} and Martins, \{Ralph N.\} and Villemagne, \{Victor L.\} and Rowe, \{Christopher C.\} and Masters, \{Colin L.\} and Coulson, \{Elizabeth J.\} and Jurgen Fripp",

note = "Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2023",

month = dec,

doi = "10.1016/j.neurobiolaging.2023.09.002",

language = "English",

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AU - Xia, Ying

AU - Maruff, Paul

AU - Doré, Vincent

AU - Bourgeat, Pierrick

AU - Laws, Simon M.

AU - Fowler, Christopher

AU - Rainey-Smith, Stephanie R.

AU - Martins, Ralph N.

AU - Villemagne, Victor L.

AU - Rowe, Christopher C.

AU - Masters, Colin L.

AU - Coulson, Elizabeth J.

AU - Fripp, Jurgen

N1 - Copyright the Author(s) 2023. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2023/12

Y1 - 2023/12

N2 - Dysfunction of the cholinergic basal forebrain (BF) system and amyloid-β (Aβ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ−, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was much greater in the predominantly cholinergic subregion of Ch4p, whereas no difference was observed for the Ch1/Ch2 region. The findings support early and substantial vulnerability of the BF and further reveal distinctive degeneration of BF subregions during early AD.

AB - Dysfunction of the cholinergic basal forebrain (BF) system and amyloid-β (Aβ) deposition are early pathological features in Alzheimer's disease (AD). However, their association in early AD is not well-established. This study investigated the nature and magnitude of volume loss in the BF, over an extended period, in 516 older adults who completed Aβ-PET and serial magnetic resonance imaging scans. Individuals were grouped at baseline according to the presence of cognitive impairment (CU, CI) and Aβ status (Aβ−, Aβ+). Longitudinal volumetric changes in the BF and hippocampus were assessed across groups. The results indicated that high Aβ levels correlated with faster volume loss in the BF and hippocampus, and the effect of Aβ varied within BF subregions. Compared to CU Aβ+ individuals, Aβ-related loss among CI Aβ+ adults was much greater in the predominantly cholinergic subregion of Ch4p, whereas no difference was observed for the Ch1/Ch2 region. The findings support early and substantial vulnerability of the BF and further reveal distinctive degeneration of BF subregions during early AD.

KW - Alzheimer's disease

KW - Amyloid-β

KW - basal forebrain

KW - longitudinal

KW - magnetic resonance imaging

UR - https://www.scopus.com/pages/publications/85173166887

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DO - 10.1016/j.neurobiolaging.2023.09.002

M3 - Article

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AN - SCOPUS:85173166887

SN - 0197-4580

VL - 132

SP - 120

EP - 130

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Longitudinal trajectories of basal forebrain volume in normal aging and Alzheimer's disease

Abstract

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Keywords

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