Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression

N. C. Dracopoli, P. Harnett, S. J. Bale, B. Z. Stanger, M. A. Tucker, D. E. Housman, R. F. Kefford

Research output: Contribution to journalArticle

208 Citations (Scopus)

Abstract

The gene for familial malignant melanoma and its precursor lesion, the dysplastic nevus, has been assigned to a region of the distal short arm of chromosome 1, which is frequently involved in karyotypic abnormalities in melanoma cells. We have examined loci on chromosome 1p for loss-of-constitutional heterozygosity in 35 melanomas and 21 melanoma cell lines to analyze the role of these abnormalities in melanocyte transformation. Loss-of-heterozygosity at loci on chromosome 1p was identified in 15/35 (43%) melanomas and 11/21 (52%) melanoma cell lines. Analysis of multiple metastases derived from the same patient and of melanoma and lymphoblastoid samples from a family with hereditary melanoma showed that the loss-of-heterozygosity at loci on distal 1p is a late event in tumor progression, rather than the second mutation that would occur if melanoma were due to a cellular recessive mechanism. Comparisons with neuroblastoma and multiple endocrine neoplasia (MEN2) suggest that the frequent 1p loss-of-heterozygosity in these malignancies is a common late event of neuroectodermal tumor progression.

Original languageEnglish
Pages (from-to)4614-4618
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume86
Issue number12
Publication statusPublished - 1989
Externally publishedYes

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