Loss of soil microbial diversity exacerbates spread of antibiotic resistance

Qing-Lin Chen, Xin-Li An, Bang-Xiao Zheng, Michael Gillings, Josep Peñuelas, Li Cui, Jian-Qiang Su, Yong-Guan Zhu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Loss of biodiversity is a major threat to the ecosystem processes upon which society depends. Natural ecosystems differ in their resistance to invasion by alien species, and this resistance can depend on the diversity in the system. Little is known, however, about the barriers that microbial diversity provides against microbial invasion. The increasing prevalence of antibiotic-resistant bacteria is a serious threat to public health in the 21st century. We explored the consequences of the reduction in soil microbial diversity for the dissemination of antibiotic resistance. The relationship between this diversity and the invasion of antibiotic resistance was investigated using a dilution-to-extinction approach coupled with high-capacity quantitative PCR. Microbial diversity was negatively correlated with the abundance of antibiotic-resistance genes, and this correlation was maintained after accounting for other potential drivers such as incubation time and microbial abundance. Our results demonstrate that high microbial diversity can act as a biological barrier resist the spread of antibiotic resistance. These results fill a critical gap in our understanding of the role of soil microbial diversity in the health of ecosystems.

Original languageEnglish
Pages (from-to)3-13
Number of pages11
JournalSoil Ecology Letters
Volume1
Issue number1-2
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Biodiversity
  • Biological barrier
  • Invasiveness
  • Ecosystem functioning

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