Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults

Julie Lasselin; Mike K. Kemani; Marie Kanstrup; Gunnar L. Olsson; John Axelsson; Anna Andreasson; Mats Lekander; Rikard K. Wicksell

doi:10.1007/s10865-016-9769-z

Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults

Julie Lasselin^*, Mike K. Kemani, Marie Kanstrup, Gunnar L. Olsson, John Axelsson, Anna Andreasson, Mats Lekander, Rikard K. Wicksell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response.

Original language	English
Pages (from-to)	916-924
Number of pages	9
Journal	Journal of Behavioral Medicine
Volume	39
Issue number	5
DOIs	https://doi.org/10.1007/s10865-016-9769-z
Publication status	Published - 1 Oct 2016
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Chronic low-grade inflammation
Chronic pain
Cognitive behavioral therapy (CBT)
Cytokines
Psychological inflexibility
Treatment responders

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10.1007/s10865-016-9769-z

Publisher versionFinal published version, 499 KBLicence: CC BY

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title = "Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults",

abstract = "The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response.",

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T1 - Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults

AU - Lasselin, Julie

AU - Kemani, Mike K.

AU - Kanstrup, Marie

AU - Olsson, Gunnar L.

AU - Axelsson, John

AU - Andreasson, Anna

AU - Lekander, Mats

AU - Wicksell, Rikard K.

N1 - Copyright the Author(s) 2016. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response.

AB - The purpose of the present pilot study was to explore the moderating role of basal inflammation on the effects of behavioral pain treatment in 41 patients with long-standing pain. Baseline pro-inflammatory status moderated behavioral treatment outcomes: higher pre-treatment levels of Tumor Necrosis Factor (TNF)-α and Interleukin (IL)-6 were related to less improvement in pain intensity, psychological inflexibility and in mental health-related quality of life. The treatment outcomes improved in the subgroup that had low levels of pro-inflammatory cytokines at baseline, while the subjects with higher pro-inflammatory status did not. Altogether, results indicate that low-grade inflammation may influence the behavioral treatment outcomes and provide a possible explanation of the heterogeneity in treatment response.

KW - Chronic low-grade inflammation

KW - Chronic pain

KW - Cognitive behavioral therapy (CBT)

KW - Cytokines

KW - Psychological inflexibility

KW - Treatment responders

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SP - 916

EP - 924

JO - Journal of Behavioral Medicine

JF - Journal of Behavioral Medicine

IS - 5

ER -

Low-grade inflammation may moderate the effect of behavioral treatment for chronic pain in adults

Abstract

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Keywords

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