Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Alexander Gillis, Arisbel B. Gondin, Andrea Kliewer, Julie Sanchez, Herman D. Lim, Claudia Alamein, Preeti Manandhar, Marina Santiago, Sebastian Fritzwanker, Frank Schmidel, Timothy A. Katte, Tristan Reekie, Natasha L. Grimsey, Michael Kassiou, Barrie Kellam, Cornelius Krasel, Michelle L. Halls, Mark Connor, J. Robert Lane, Stefan SchulzMacdonald J. Christie, Meritxell Canals

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Medicine & Life Sciences