Lower in vivo myo-inositol in the anterior cingulate cortex correlates with delayed melatonin rhythms in young persons with depression

Rébecca Robillard*, Jim Lagopoulos, Daniel F. Hermens, Sharon L. Naismith, Naomi L. Rogers, Django White, Joanne S. Carpenter, Manreena Kaur, Elizabeth M. Scott, Ian B. Hickie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)
2 Downloads (Pure)

Abstract

Myo-inositol, a second messenger glucose isomer and glial marker, is potentiated by melatonin. In addition to common abnormalities in melatonin regulation, depressive disorders have been associated with reduced myo-inositol in frontal structures. This study examined associations between myo-inositol in the anterior cingulate cortex and the timing of evening melatonin release. Forty young persons with unipolar depression were recruited from specialized mental health services (20.3 ± 3.8 years old). Healthy controls were recruited from the community (21.7 ± 2.6 years old). The timing of dim light melatonin onset (DLMO) was estimated using salivary melatonin sampling. Myo-inositol concentrations (MI/CrPCr ratio) in the anterior cingulate cortex were obtained using proton magnetic resonance spectroscopy. After controlling for age, sex, and CrPCr concentration the depression group had significantly lower MI/CrPCr ratios than healthy controls [F(4, 75) = 11.4, p = 0.001]. In the depression group, later DLMO correlated with lower MI/CrPCr ratio (r = -0.48, p = 0.014). These findings suggest that neurochemical changes in the frontal cortex are associated with circadian disruptions in young persons with depression.

Original languageEnglish
Article number336
Pages (from-to)1-6
Number of pages6
JournalFrontiers in Neuroscience
Volume11
Issue numberJUN
DOIs
Publication statusPublished - 20 Jun 2017
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2017. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • melatonin
  • depression
  • magnetic resonance spectroscopy
  • myo-inositol
  • circadian

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