Lower-limb lymphatic drainage pathways and lymph nodes: a CT lymphangiography cadaver study

Akira Shinaoka, Seijiro Koshimune, Hiroo Suami, Kiyoshi Yamada, Kanae Kumagishi, John Boyages, Yoshihiro Kimata, Aiji Ohtsuka

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Most lymphatic imaging examinations of the lower limb require intradermal or subcutaneous injection of tracer material into the foot to demonstrate the lymphatic vessels; however, no standard protocol exists, and single or multiple injections are applied at different sites. Purpose: To determine the three-dimensional relationships between each lymphatic group of the lower limb and corresponding regional lymph nodes. Materials and Methods: A total of 130 lower limbs (55 from men and 75 from women) from 83 fresh human cadavers were studied. Lymphatic vessels were first visualized by using indocyanine green fluorescent lymphography with 19 injection sites in the foot, classified into four distinct lymphatic groups (anteromedial, anterolateral, posteromedial, and posterolateral); dilute oil-based contrast material was then injected. Next, specimens were scanned with CT and three-dimensional images were analyzed. Results: The anteromedial and anterolateral lymphatic groups of the lower-leg lymphatic vessels were independent of each other and connected to different regional lymph nodes in the inguinal region. The posteromedial group and the anteromedial group in the lower leg drained to the same inguinal lymph nodes. Only the posterolateral group of lymphatic vessels in the lower leg drained to the popliteal lymph nodes. Leg lymphatic drainage pathways were independent of genital pathways. Conclusion: Standard injection sites at the web spaces between the toes did not help visualize some lymph nodes of the lower leg. Additional injection sites in the medial, lateral, and posterior aspect of the foot would be better for evaluating the whole lymphatic pathways and regional lymph nodes and for improving understanding of leg lymphedema.

LanguageEnglish
Pages223-229
Number of pages7
JournalRadiology
Volume294
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

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Lymphography
Cadaver
Drainage
Lower Extremity
Leg
Lymphatic Vessels
Lymph Nodes
Foot
Injections
Groin
Intradermal Injections
Indocyanine Green
Lymphedema
Three-Dimensional Imaging
Toes
Subcutaneous Injections
Contrast Media
Oils

Cite this

Shinaoka, Akira ; Koshimune, Seijiro ; Suami, Hiroo ; Yamada, Kiyoshi ; Kumagishi, Kanae ; Boyages, John ; Kimata, Yoshihiro ; Ohtsuka, Aiji. / Lower-limb lymphatic drainage pathways and lymph nodes : a CT lymphangiography cadaver study. In: Radiology. 2020 ; Vol. 294, No. 1. pp. 223-229.
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abstract = "Background: Most lymphatic imaging examinations of the lower limb require intradermal or subcutaneous injection of tracer material into the foot to demonstrate the lymphatic vessels; however, no standard protocol exists, and single or multiple injections are applied at different sites. Purpose: To determine the three-dimensional relationships between each lymphatic group of the lower limb and corresponding regional lymph nodes. Materials and Methods: A total of 130 lower limbs (55 from men and 75 from women) from 83 fresh human cadavers were studied. Lymphatic vessels were first visualized by using indocyanine green fluorescent lymphography with 19 injection sites in the foot, classified into four distinct lymphatic groups (anteromedial, anterolateral, posteromedial, and posterolateral); dilute oil-based contrast material was then injected. Next, specimens were scanned with CT and three-dimensional images were analyzed. Results: The anteromedial and anterolateral lymphatic groups of the lower-leg lymphatic vessels were independent of each other and connected to different regional lymph nodes in the inguinal region. The posteromedial group and the anteromedial group in the lower leg drained to the same inguinal lymph nodes. Only the posterolateral group of lymphatic vessels in the lower leg drained to the popliteal lymph nodes. Leg lymphatic drainage pathways were independent of genital pathways. Conclusion: Standard injection sites at the web spaces between the toes did not help visualize some lymph nodes of the lower leg. Additional injection sites in the medial, lateral, and posterior aspect of the foot would be better for evaluating the whole lymphatic pathways and regional lymph nodes and for improving understanding of leg lymphedema.",
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Shinaoka, A, Koshimune, S, Suami, H, Yamada, K, Kumagishi, K, Boyages, J, Kimata, Y & Ohtsuka, A 2020, 'Lower-limb lymphatic drainage pathways and lymph nodes: a CT lymphangiography cadaver study', Radiology, vol. 294, no. 1, pp. 223-229. https://doi.org/10.1148/radiol.2019191169

Lower-limb lymphatic drainage pathways and lymph nodes : a CT lymphangiography cadaver study. / Shinaoka, Akira; Koshimune, Seijiro; Suami, Hiroo; Yamada, Kiyoshi; Kumagishi, Kanae; Boyages, John; Kimata, Yoshihiro; Ohtsuka, Aiji.

In: Radiology, Vol. 294, No. 1, 01.01.2020, p. 223-229.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Lower-limb lymphatic drainage pathways and lymph nodes

T2 - Radiology

AU - Shinaoka, Akira

AU - Koshimune, Seijiro

AU - Suami, Hiroo

AU - Yamada, Kiyoshi

AU - Kumagishi, Kanae

AU - Boyages, John

AU - Kimata, Yoshihiro

AU - Ohtsuka, Aiji

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N2 - Background: Most lymphatic imaging examinations of the lower limb require intradermal or subcutaneous injection of tracer material into the foot to demonstrate the lymphatic vessels; however, no standard protocol exists, and single or multiple injections are applied at different sites. Purpose: To determine the three-dimensional relationships between each lymphatic group of the lower limb and corresponding regional lymph nodes. Materials and Methods: A total of 130 lower limbs (55 from men and 75 from women) from 83 fresh human cadavers were studied. Lymphatic vessels were first visualized by using indocyanine green fluorescent lymphography with 19 injection sites in the foot, classified into four distinct lymphatic groups (anteromedial, anterolateral, posteromedial, and posterolateral); dilute oil-based contrast material was then injected. Next, specimens were scanned with CT and three-dimensional images were analyzed. Results: The anteromedial and anterolateral lymphatic groups of the lower-leg lymphatic vessels were independent of each other and connected to different regional lymph nodes in the inguinal region. The posteromedial group and the anteromedial group in the lower leg drained to the same inguinal lymph nodes. Only the posterolateral group of lymphatic vessels in the lower leg drained to the popliteal lymph nodes. Leg lymphatic drainage pathways were independent of genital pathways. Conclusion: Standard injection sites at the web spaces between the toes did not help visualize some lymph nodes of the lower leg. Additional injection sites in the medial, lateral, and posterior aspect of the foot would be better for evaluating the whole lymphatic pathways and regional lymph nodes and for improving understanding of leg lymphedema.

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