Lung function in mid-life compared with later life is a stronger predictor of arterial stiffness in men

The Caerphilly Prospective Study

Charlotte E. Bolton*, John R. Cockcroft, Ramsey Sabit, Margaret Munnery, Carmel M. McEniery, Ian B. Wilkinson, Shah Ebrahim, John E. Gallacher, Dennis J. Shale, Yoav Ben-Shlomo

*Corresponding author for this work

    Research output: Contribution to journalArticle

    44 Citations (Scopus)


    Background: Increased arterial stiffness predicts future cardiovascular disease and in some cross-sectional studies it is related to worse lung function and obstructive pulmonary disease. We assessed the predictive value of lung function measured in mid-life as compared with later life on arterial stiffness in the Caerphilly Prospective Study (CaPS). Methods: Men aged 47-67 years had lung function measured between 1984 and 1988 and repeated between 2002 and 2004 (n = 827) as well as having carotid-femoral pulse wave velocity (PWV) measured. Results: Both forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in mid-life and later life were inversely associated with PWV (P < 0.0001) but mid-life measures were stronger predictors. Only mid-life measures remained predictors after mutual adjustment (FEV1 mid-life β coeff. -0.65, 95% CI -1.04, -0.26, P < 0.0001; FVC mid-life β coeff. -0.52, 95% CI -0.82, -0.23, P < 0.0001). Adjustment for smoking status, early life, inflammatory and metabolic factors in sub-groups did not markedly change the associations. Conclusions: Mid-life lung function is a stronger risk factor than in later life for arterial stiffness in men. It is possible that developmental factors influence both lung function and arterial stiffness. Lung function assessment in mid-life may identify individuals at greater risk of their future cardiovascular disease. Published by Oxford University Press on behalf of the International Epidemiological Association

    Original languageEnglish
    Pages (from-to)867-876
    Number of pages10
    JournalInternational Journal of Epidemiology
    Issue number3
    Publication statusPublished - 2009


    • Arterial stiffness
    • Cardiovascular disease
    • Epidemiology
    • Lung function

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