TY - JOUR
T1 - Luteolin as an anti-inflammatory and neuroprotective agent
T2 - a brief review
AU - Nabavi, Seyed Fazel
AU - Braidy, Nady
AU - Gortzi, Olga
AU - Sobarzo-Sanchez, Eduardo
AU - Daglia, Maria
AU - Skalicka-Woźniak, Krystyna
AU - Nabavi, Seyed Mohammad
PY - 2015/10/1
Y1 - 2015/10/1
N2 - According to the World Health Organization, two billion people will be aged 60 years or older by 2050. Aging is a major risk factor for a number of neurodegenerative disorders. These age-related disorders currently represent one of the most important and challenging health problems worldwide. Therefore, much attention has been directed towards the design and development of neuroprotective agents derived from natural sources. These phytochemicals have demonstrated high efficacy and low adverse effects in multiple in vitro and in vivo studies. Among these phytochemicals, dietary flavonoids are an important and common chemical class of bioactive products, found in several fruits and vegetables. Luteolin is an important flavone, which is found in several plant products, including broccoli, pepper, thyme, and celery. Numerous studies have shown that luteolin possesses beneficial neuroprotective effects both in vitro and in vivo. Despite this, an overview of the neuroprotective effects of luteolin has not yet been accomplished. Therefore, the aim of this paper is to provide a review of the available literature regarding the neuroprotective effects of luteolin and its molecular mechanisms of action. Herein, we also review the available literature regarding the chemistry of luteolin, its herbal sources, and bioavailability as a pharmacological agent for the treatment and management of age-related neurodegenerative disorders.
AB - According to the World Health Organization, two billion people will be aged 60 years or older by 2050. Aging is a major risk factor for a number of neurodegenerative disorders. These age-related disorders currently represent one of the most important and challenging health problems worldwide. Therefore, much attention has been directed towards the design and development of neuroprotective agents derived from natural sources. These phytochemicals have demonstrated high efficacy and low adverse effects in multiple in vitro and in vivo studies. Among these phytochemicals, dietary flavonoids are an important and common chemical class of bioactive products, found in several fruits and vegetables. Luteolin is an important flavone, which is found in several plant products, including broccoli, pepper, thyme, and celery. Numerous studies have shown that luteolin possesses beneficial neuroprotective effects both in vitro and in vivo. Despite this, an overview of the neuroprotective effects of luteolin has not yet been accomplished. Therefore, the aim of this paper is to provide a review of the available literature regarding the neuroprotective effects of luteolin and its molecular mechanisms of action. Herein, we also review the available literature regarding the chemistry of luteolin, its herbal sources, and bioavailability as a pharmacological agent for the treatment and management of age-related neurodegenerative disorders.
KW - Alzheimer's disease
KW - Flavonoid
KW - Luteolin
KW - Neurotoxicity
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=84944079121&partnerID=8YFLogxK
U2 - 10.1016/j.brainresbull.2015.09.002
DO - 10.1016/j.brainresbull.2015.09.002
M3 - Review article
C2 - 26361743
AN - SCOPUS:84944079121
VL - 119
SP - 1
EP - 11
JO - Brain Research Bulletin
JF - Brain Research Bulletin
SN - 0361-9230
ER -