Lymph node ratio as an independent prognostic factor in oral squamous cell carcinoma

Ardalan Ebrahimi*, Jonathan R. Clark, Wan Jing Zhang, Michel S. Elliott, Kan Gao, Christopher G. Milross, Kerwin F. Shannon

*Corresponding author for this work

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background We aimed to validate the lymph node ratio (LNR) as an independent prognostic factor in oral squamous cell carcinoma (OSCC) and compare its utility with the current nodal staging system. Methods We conducted a retrospective analysis of 313 patients with OSCC undergoing neck dissection. The LNR was adjusted by relevant covariates in a multivariable Cox regression model. Results LNR displaced conventional nodal staging and was shown to be an independent predictor of regional failure (p =.020), disease-specific (p =.003) and overall survival (p =.001). Patients with an LNR of 2.5% to 7.5%, 7.5% to 20%, and >20% had 2.6, 3.7, and 4.4 times the risk of death from OSCC, respectively, when compared with patients with an LNR <2.5%. Conclusions The LNR is an independent prognostic factor in OSCC and may be used in conjunction with the current TNM staging to enable better risk stratification and selection for adjuvant therapy. © 2010 Wiley Periodicals, Inc. Head Neck, 2010

Original languageEnglish
Pages (from-to)1245-1251
Number of pages7
JournalHead and Neck
Volume33
Issue number9
DOIs
Publication statusPublished - Sep 2011
Externally publishedYes

Keywords

  • head and neck
  • lymph nodes
  • oral cancer
  • squamous cell carcinoma
  • survival

Fingerprint Dive into the research topics of 'Lymph node ratio as an independent prognostic factor in oral squamous cell carcinoma'. Together they form a unique fingerprint.

Cite this