Lysine metabolism in mammalian brain: An update on the importance of recent discoveries

André Hallen, Joanne F. Jamie, Arthur J L Cooper

Research output: Contribution to journalReview articleResearchpeer-review

Abstract

The lysine catabolism pathway differs in adult mammalian brain from that in extracerebral tissues. The saccharopine pathway is the predominant lysine degradative pathway in extracerebral tissues, whereas the pipecolate pathway predominates in adult brain. The two pathways converge at the level of δ1-piperideine-6-carboxylate (P6C), which is in equilibrium with its open-chain aldehyde form, namely, α-aminoadipate δ-semialdehyde (AAS). A unique feature of the pipecolate pathway is the formation of the cyclic ketimine intermediate δ1-piperideine-2- carboxylate (P2C) and its reduced metabolite l-pipecolate. A cerebral ketimine reductase (KR) has recently been identified that catalyzes the reduction of P2C to l-pipecolate. The discovery that this KR, which is capable of reducing not only P2C but also other cyclic imines, is identical to a previously well-described thyroid hormone-binding protein [μ-crystallin (CRYM)], may hold the key to understanding the biological relevance of the pipecolate pathway and its importance in the brain. The finding that the KR activity of CRYM is strongly inhibited by the thyroid hormone 3,5,3′-triiodothyronine (T 3) has far-reaching biomedical and clinical implications. The inter-relationship between tryptophan and lysine catabolic pathways is discussed in the context of shared degradative enzymes and also potential regulation by thyroid hormones. This review traces the discoveries of enzymes involved in lysine metabolism in mammalian brain. However, there still remain unanswered questions as regards the importance of the pipecolate pathway in normal or diseased brain, including the nature of the first step in the pathway and the relationship of the pipecolate pathway to the tryptophan degradation pathway.

LanguageEnglish
Pages1249-1272
Number of pages24
JournalAmino Acids
Volume45
Issue number6
DOIs
Publication statusPublished - Dec 2013

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Metabolism
Lysine
Brain
Thyroid Hormones
Tryptophan
Imines
Tissue
Brain Diseases
Triiodothyronine
Enzymes
Aldehydes
Metabolites
Degradation
ketimine reductase

Cite this

Hallen, André ; Jamie, Joanne F. ; Cooper, Arthur J L. / Lysine metabolism in mammalian brain : An update on the importance of recent discoveries. In: Amino Acids. 2013 ; Vol. 45, No. 6. pp. 1249-1272.
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Lysine metabolism in mammalian brain : An update on the importance of recent discoveries. / Hallen, André; Jamie, Joanne F.; Cooper, Arthur J L.

In: Amino Acids, Vol. 45, No. 6, 12.2013, p. 1249-1272.

Research output: Contribution to journalReview articleResearchpeer-review

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