Mössbauer evidence of 57Fe3O4 based ferrofluid biodegradation in the brain

D. Polikarpov; V. Cherepanov; M. Chuev; R. Gabbasov; I. Mischenko; M. Nikitin; Y. Vereshagin; A. Yurenia; V. Panchenko

doi:10.1007/s10751-013-1002-7

Mössbauer evidence of ⁵⁷Fe₃O₄ based ferrofluid biodegradation in the brain

D. Polikarpov^*, V. Cherepanov, M. Chuev, R. Gabbasov, I. Mischenko, M. Nikitin, Y. Vereshagin, A. Yurenia, V. Panchenko

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

The ferrofluid, based on ⁵⁷Fe isotope enriched Fe₃O₄ nanoparticles, was synthesized, investigated by Mössbauer spectroscopy method and injected transcranially in the ventricle of the rat brain. The comparison of the Mössbauer spectra of the initial ferrofluid and the rat brain measured in two hours and one week after the transcranial injection allows us to state that the synthesized magnetic ⁵⁷Fe₃O₄ nanoparticles undergo intensive biodegradation in live brain and, therefore, they can be regarded as a promising target for a new method of radionuclide-free Mössbauer brachytherapy.

Original language	English
Pages (from-to)	421-430
Number of pages	10
Journal	Hyperfine Interactions
Volume	226
Issue number	1-3
DOIs	https://doi.org/10.1007/s10751-013-1002-7
Publication status	Published - Apr 2014
Externally published	Yes

Keywords

brain
magnetic nanoparticles
Mössbauer spectroscopy

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10.1007/s10751-013-1002-7

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title = "M{\"o}ssbauer evidence of 57Fe3O4 based ferrofluid biodegradation in the brain",

abstract = "The ferrofluid, based on 57Fe isotope enriched Fe3O4 nanoparticles, was synthesized, investigated by M{\"o}ssbauer spectroscopy method and injected transcranially in the ventricle of the rat brain. The comparison of the M{\"o}ssbauer spectra of the initial ferrofluid and the rat brain measured in two hours and one week after the transcranial injection allows us to state that the synthesized magnetic 57Fe3O4 nanoparticles undergo intensive biodegradation in live brain and, therefore, they can be regarded as a promising target for a new method of radionuclide-free M{\"o}ssbauer brachytherapy.",

keywords = "brain, magnetic nanoparticles, M{\"o}ssbauer spectroscopy",

author = "D. Polikarpov and V. Cherepanov and M. Chuev and R. Gabbasov and I. Mischenko and M. Nikitin and Y. Vereshagin and A. Yurenia and V. Panchenko",

year = "2014",

month = apr,

doi = "10.1007/s10751-013-1002-7",

language = "English",

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T1 - Mössbauer evidence of 57Fe3O4 based ferrofluid biodegradation in the brain

AU - Polikarpov, D.

AU - Cherepanov, V.

AU - Chuev, M.

AU - Gabbasov, R.

AU - Mischenko, I.

AU - Nikitin, M.

AU - Vereshagin, Y.

AU - Yurenia, A.

AU - Panchenko, V.

PY - 2014/4

Y1 - 2014/4

N2 - The ferrofluid, based on 57Fe isotope enriched Fe3O4 nanoparticles, was synthesized, investigated by Mössbauer spectroscopy method and injected transcranially in the ventricle of the rat brain. The comparison of the Mössbauer spectra of the initial ferrofluid and the rat brain measured in two hours and one week after the transcranial injection allows us to state that the synthesized magnetic 57Fe3O4 nanoparticles undergo intensive biodegradation in live brain and, therefore, they can be regarded as a promising target for a new method of radionuclide-free Mössbauer brachytherapy.

AB - The ferrofluid, based on 57Fe isotope enriched Fe3O4 nanoparticles, was synthesized, investigated by Mössbauer spectroscopy method and injected transcranially in the ventricle of the rat brain. The comparison of the Mössbauer spectra of the initial ferrofluid and the rat brain measured in two hours and one week after the transcranial injection allows us to state that the synthesized magnetic 57Fe3O4 nanoparticles undergo intensive biodegradation in live brain and, therefore, they can be regarded as a promising target for a new method of radionuclide-free Mössbauer brachytherapy.

KW - brain

KW - magnetic nanoparticles

KW - Mössbauer spectroscopy

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DO - 10.1007/s10751-013-1002-7

M3 - Article

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VL - 226

SP - 421

EP - 430

JO - Hyperfine Interactions

JF - Hyperfine Interactions

SN - 0304-3843

IS - 1-3

ER -

Mössbauer evidence of ⁵⁷Fe₃O₄ based ferrofluid biodegradation in the brain

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Keywords

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