Mössbauer evidence of 57Fe3O4 based ferrofluid biodegradation in the brain

D. Polikarpov*, V. Cherepanov, M. Chuev, R. Gabbasov, I. Mischenko, M. Nikitin, Y. Vereshagin, A. Yurenia, V. Panchenko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The ferrofluid, based on 57Fe isotope enriched Fe3O4 nanoparticles, was synthesized, investigated by Mössbauer spectroscopy method and injected transcranially in the ventricle of the rat brain. The comparison of the Mössbauer spectra of the initial ferrofluid and the rat brain measured in two hours and one week after the transcranial injection allows us to state that the synthesized magnetic 57Fe3O4 nanoparticles undergo intensive biodegradation in live brain and, therefore, they can be regarded as a promising target for a new method of radionuclide-free Mössbauer brachytherapy.

Original languageEnglish
Pages (from-to)421-430
Number of pages10
JournalHyperfine Interactions
Volume226
Issue number1-3
DOIs
Publication statusPublished - Apr 2014
Externally publishedYes

Keywords

  • brain
  • magnetic nanoparticles
  • Mössbauer spectroscopy

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