Macrogonadotropinoma, a venous thromboembolic event and asymptomatic extensive periventricular white matter changes in a patient with Klinefelter syndrome

Divya Namboodiri; Hui Yi Ng; Aakansha Zala; John Magnussen; Andrew Davidson; Bernard Champion; Veronica Preda

doi:10.1002/ccr3.2714

Macrogonadotropinoma, a venous thromboembolic event and asymptomatic extensive periventricular white matter changes in a patient with Klinefelter syndrome

Divya Namboodiri^*, Hui Yi Ng, Aakansha Zala, John Magnussen, Andrew Davidson, Bernard Champion, Veronica Preda

^*Corresponding author for this work

Faculty of Medicine, Health and Human Sciences

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Abstract

Gonadotropinoma in Klinefelter syndrome (KS) is uncommon and may be a result of protracted stimulation of gonadotrophs from lack of androgen feedback. Associations of white matter changes and increased venous thromboembolic risk have been reported and need to be considered in patients with KS.

Original language	English
Pages (from-to)	675-679
Number of pages	5
Journal	Clinical Case Reports
Volume	8
Issue number	4
Early online date	4 Mar 2020
DOIs	https://doi.org/10.1002/ccr3.2714
Publication status	Published - Apr 2020

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Klinefelter syndrome
macrogonadotropinoma
periventricular white matter changes
pulmonary embolism
venous thromboembolism

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10.1002/ccr3.2714Licence: CC BY-NC-ND

Publisher version (open access)Final published version, 472 KBLicence: CC BY-NC-ND

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abstract = "Gonadotropinoma in Klinefelter syndrome (KS) is uncommon and may be a result of protracted stimulation of gonadotrophs from lack of androgen feedback. Associations of white matter changes and increased venous thromboembolic risk have been reported and need to be considered in patients with KS.",

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AU - Namboodiri, Divya

AU - Ng, Hui Yi

AU - Zala, Aakansha

AU - Magnussen, John

AU - Davidson, Andrew

AU - Champion, Bernard

AU - Preda, Veronica

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N2 - Gonadotropinoma in Klinefelter syndrome (KS) is uncommon and may be a result of protracted stimulation of gonadotrophs from lack of androgen feedback. Associations of white matter changes and increased venous thromboembolic risk have been reported and need to be considered in patients with KS.

AB - Gonadotropinoma in Klinefelter syndrome (KS) is uncommon and may be a result of protracted stimulation of gonadotrophs from lack of androgen feedback. Associations of white matter changes and increased venous thromboembolic risk have been reported and need to be considered in patients with KS.

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KW - macrogonadotropinoma

KW - periventricular white matter changes

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KW - venous thromboembolism

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Macrogonadotropinoma, a venous thromboembolic event and asymptomatic extensive periventricular white matter changes in a patient with Klinefelter syndrome

Abstract

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