Macromolecular crowding and hydrophobic effects on Fmoc-diphenylalanine hydrogel formation in PEG:water mixtures

Md. Musfizur Hassan; Adam D. Martin; Pall Thordarson

doi:10.1039/c5tb02139a

Macromolecular crowding and hydrophobic effects on Fmoc-diphenylalanine hydrogel formation in PEG:water mixtures

Md. Musfizur Hassan, Adam D. Martin, Pall Thordarson

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

64 Downloads (Pure)

Abstract

A small peptide-based gelator forms stable hydrogels in an aqueous mixture with a range of poly(ethylene glycol) PEGs, from the ethylene glycol monomer to PEG 20 000 with stronger gels forming in polymeric PEG. Spectroscopic studies on these systems reveal significant secondary structural changes when compared to gels formed from pure water. The use of PEG also facilitates the incorporation and controlled release of poorly water-soluble anti-cancer drugs such as Temozolomide and Paclitaxel (Taxol®). This work provides a powerful insight into the role of macromolecular crowding and hydrophobic interactions in not only hydrogels formed from small molecules but potentially also biological gel-like materials such as the cytosol and the extracellular matrix (ECM).

Original language	English
Pages (from-to)	9269-9276
Number of pages	8
Journal	Journal of Materials Chemistry B
Volume	3
Issue number	48
DOIs	https://doi.org/10.1039/c5tb02139a
Publication status	Published - 2015
Externally published	Yes

Bibliographical note

Copyright The Royal Society of Chemistry 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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10.1039/c5tb02139a

Publisher version (open access)Final published version, 1.98 MBLicence: CC BY-NC

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Cite this

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abstract = "A small peptide-based gelator forms stable hydrogels in an aqueous mixture with a range of poly(ethylene glycol) PEGs, from the ethylene glycol monomer to PEG 20 000 with stronger gels forming in polymeric PEG. Spectroscopic studies on these systems reveal significant secondary structural changes when compared to gels formed from pure water. The use of PEG also facilitates the incorporation and controlled release of poorly water-soluble anti-cancer drugs such as Temozolomide and Paclitaxel (Taxol{\textregistered}). This work provides a powerful insight into the role of macromolecular crowding and hydrophobic interactions in not only hydrogels formed from small molecules but potentially also biological gel-like materials such as the cytosol and the extracellular matrix (ECM).",

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AU - Hassan, Md. Musfizur

AU - Martin, Adam D.

AU - Thordarson, Pall

N1 - Copyright The Royal Society of Chemistry 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2015

Y1 - 2015

N2 - A small peptide-based gelator forms stable hydrogels in an aqueous mixture with a range of poly(ethylene glycol) PEGs, from the ethylene glycol monomer to PEG 20 000 with stronger gels forming in polymeric PEG. Spectroscopic studies on these systems reveal significant secondary structural changes when compared to gels formed from pure water. The use of PEG also facilitates the incorporation and controlled release of poorly water-soluble anti-cancer drugs such as Temozolomide and Paclitaxel (Taxol®). This work provides a powerful insight into the role of macromolecular crowding and hydrophobic interactions in not only hydrogels formed from small molecules but potentially also biological gel-like materials such as the cytosol and the extracellular matrix (ECM).

AB - A small peptide-based gelator forms stable hydrogels in an aqueous mixture with a range of poly(ethylene glycol) PEGs, from the ethylene glycol monomer to PEG 20 000 with stronger gels forming in polymeric PEG. Spectroscopic studies on these systems reveal significant secondary structural changes when compared to gels formed from pure water. The use of PEG also facilitates the incorporation and controlled release of poorly water-soluble anti-cancer drugs such as Temozolomide and Paclitaxel (Taxol®). This work provides a powerful insight into the role of macromolecular crowding and hydrophobic interactions in not only hydrogels formed from small molecules but potentially also biological gel-like materials such as the cytosol and the extracellular matrix (ECM).

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DO - 10.1039/c5tb02139a

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EP - 9276

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 48

ER -

Macromolecular crowding and hydrophobic effects on Fmoc-diphenylalanine hydrogel formation in PEG:water mixtures

Abstract

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