Macrophage inhibitory cytokine 1 (MIC-1/GDF15) decreases food intake, body weight and improves glucose tolerance in mice on normal & obesogenic diets

Laurence Macia*, Vicky Wang-Wei Tsai, Amy D. Nguyen, Heiko Johnen, Tamara Kuffner, Yan-Chuan Shi, Shu Lin, Herbert Herzog, David A. Brown, Samuel N. Breit, Amanda Sainsbury

*Corresponding author for this work

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory cytokine-1 (MIC-1/GDF15), known to have anorexigenic effects particularly in cancer, provides protection against the development of obesity. Both under a normal chow diet and an obesogenic diet, the transgenic overexpression of MIC-1/GDF15 in mice leads to decreased body weight and fat mass. This lean phenotype was associated with decreased spontaneous but not fasting-induced food intake, on a background of unaltered energy expenditure and reduced physical activity. Importantly, the overexpression of MIC-1/GDF15 improved glucose tolerance, both under normal and high fat-fed conditions. Altogether, this work shows that the molecule MIC-1/GDF15 might be beneficial for the treatment of obesity as well as perturbations in glucose homeostasis.

Original languageEnglish
Article number34868
Pages (from-to)1-8
Number of pages8
JournalPLoS ONE
Volume7
Issue number4
DOIs
Publication statusPublished - 13 Apr 2012
Externally publishedYes

Keywords

  • TGF-BETA SUPERFAMILY
  • NEUROPEPTIDE-Y
  • MESSENGER-RNA
  • OBESITY
  • LEPTIN
  • MELANOCORTIN
  • RESISTANCE
  • OXIDATION
  • ANOREXIA
  • INSULIN

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