Magnetised thermo responsive lipid vehicles for targeted and controlled lung drug delivery

Dhrumil Upadhyay, Santo Scalia, Robert Vogel, Nial Wheate, Rania O. Salama, Paul M. Young, Daniela Traini, Wojciech Chrzanowski

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Purpose Conditions such as lung cancer currently lack non-invasively targetable and controlled release topical inhalational therapies. Superparamagnetic iron-oxide nanoparticles (SPIONs) have shown promising results as a targetable therapy. We aimed to fabricate and test the in-vitro performance of particles with SPION and drug within a lipid matrix as a potentially targetable and thermo-sensitive inhalable drug-delivery system.

Methods Budesonide and SPIONs were incorporated into lipid particles using oil-in-water emulsification. Particles size, chemical composition, responsiveness to magnetic field, thermosensitiveness and inhalation performance in-vitro were investigated.

Results Particles of average diameter 2–4 μm with budesonide and SPIONs inside the lipid matrix responded to a magnetic field with 100% extraction at a distance of 5 mm. Formulations were shown to have accelerated rate of drug release at hyperthermic temperatures (45°C)—controlled release. The produced inhalation dry powder presented promising inhalation performance, with an inhalable fine particle fraction of 30%.

Conclusions The lipid system presented thermo-sensitive characteristics, suitable for controlled delivery, the model drug and SPION loaded lipid system was magnetically active and movable using simple permanent magnets, and the system demonstrates promise as an effective drug vehicle in targeted and controlled inhalation therapy.
Original languageEnglish
Pages (from-to)2456–2467
Number of pages12
JournalPharmaceutical Research
Volume29
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • controlled drug delivery
  • inhalation
  • iron oxide
  • lipid
  • magneto-responsive
  • thermo-responsive
  • triggered drug release

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