TY - JOUR
T1 - Magnetohydrodynamic blood flow in patients with coronary artery disease
AU - Javadzadegan, Ashkan
AU - Moshfegh, Abouzar
AU - Afrouzi, Hamid Hassanzadeh
AU - Omidi, Mohammad
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Objectives: We aim to investigate the effect of a magnetic field with varying intensities on haemodynamic perturbations in a cohort of patients with coronary artery disease. Methods: Transient computational fluid dynamics (CFD) simulations were performed in three-dimensional (3D) models of coronary arteries reconstructed from 3D quantitative coronary angiography. The effect of magnetic field on wall shear stress (WSS) derived parameters including maximum wall shear stress (MWSS) and size of regions with low wall shear stress (ALWSS) as well as length of flow recirculation zones were determined. Results: The results showed a substantial reduction in MWSS, ALWSS and length of flow recirculation zones in the presence of magnetic field, in particular for coronaries with moderate to severe stenoses. When the whole cohort examined, time-averaged wall shear stress (TAWSS), ALWSS and the length of flow recirculation zones in the absence of magnetic field were approximately 1.71, 4.69 and 8.46 times greater than those in the presence of magnetic field, respectively. Conclusion: Our findings imply that an externally applied magnetic field can improve haemodynamic perturbations in human coronary arteries.
AB - Objectives: We aim to investigate the effect of a magnetic field with varying intensities on haemodynamic perturbations in a cohort of patients with coronary artery disease. Methods: Transient computational fluid dynamics (CFD) simulations were performed in three-dimensional (3D) models of coronary arteries reconstructed from 3D quantitative coronary angiography. The effect of magnetic field on wall shear stress (WSS) derived parameters including maximum wall shear stress (MWSS) and size of regions with low wall shear stress (ALWSS) as well as length of flow recirculation zones were determined. Results: The results showed a substantial reduction in MWSS, ALWSS and length of flow recirculation zones in the presence of magnetic field, in particular for coronaries with moderate to severe stenoses. When the whole cohort examined, time-averaged wall shear stress (TAWSS), ALWSS and the length of flow recirculation zones in the absence of magnetic field were approximately 1.71, 4.69 and 8.46 times greater than those in the presence of magnetic field, respectively. Conclusion: Our findings imply that an externally applied magnetic field can improve haemodynamic perturbations in human coronary arteries.
KW - Atherosclerosis
KW - Coronary artery
KW - Haemodynamic perturbations
KW - Magnetic field
UR - http://www.scopus.com/inward/record.url?scp=85048596233&partnerID=8YFLogxK
U2 - 10.1016/j.cmpb.2018.06.007
DO - 10.1016/j.cmpb.2018.06.007
M3 - Article
VL - 163
SP - 111
EP - 122
JO - Computer Methods and Programs in Biomedicine
JF - Computer Methods and Programs in Biomedicine
SN - 0169-2607
ER -