Malignant optic glioma presenting as an acute anterior optic neuropathy

Chandra Balachandran; Michael James Millar; Rajmohan Murali; Carl Bulliard; Capon M. Malcolm; Anthony Maloof

doi:10.1097/ICB.0b013e31815f3c95

Malignant optic glioma presenting as an acute anterior optic neuropathy

Chandra Balachandran, Michael James Millar, Rajmohan Murali, Carl Bulliard, Capon M. Malcolm, Anthony Maloof

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To describe an uncommon case of malignant optic glioma and the challenges in its diagnosis.

Methods: Case report with funduscopic, magnetic resonance imaging (MRI), and automated field test correlations.

Patient: A 60-year-old man presented with a 1-week history of left optic disk swelling and optic neuropathy that was initially diagnosed as nonarteritic anterior ischemic optic neuropathy (NA-AION).

Results: His clinical course deteriorated with progressive vision loss, acute orbital inflammation, and central retinal vein and artery occlusion, despite an improvement with a short course of steroids. MRI revealed enhancement of the left optic nerve, chiasm, and left optic tract. Initial optic nerve biopsy was negative and biopsy of optic tract confirmed a diagnosis of glioblastoma multiforme grade 4. The patient died 4 months after biopsy despite chemotherapy and radiotherapy.

Conclusion: The diagnoses of malignant optic glioma, anterior ischemic optic neuropathy, and optic neuritis have significant overlap of signs and symptoms. The authors report a case that demonstrates the difficulties in diagnosis, and propose additional presenting features of malignant optic glioma.

Original language	English
Pages (from-to)	156-160
Number of pages	5
Journal	Retinal Cases and Brief Reports
Volume	3
Issue number	2
DOIs	https://doi.org/10.1097/ICB.0b013e31815f3c95
Publication status	Published - 2009
Externally published	Yes

Keywords

Journal Article

Access to Document

10.1097/ICB.0b013e31815f3c95

Cite this

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title = "Malignant optic glioma presenting as an acute anterior optic neuropathy",

abstract = "Purpose: To describe an uncommon case of malignant optic glioma and the challenges in its diagnosis.Methods: Case report with funduscopic, magnetic resonance imaging (MRI), and automated field test correlations.Patient: A 60-year-old man presented with a 1-week history of left optic disk swelling and optic neuropathy that was initially diagnosed as nonarteritic anterior ischemic optic neuropathy (NA-AION).Results: His clinical course deteriorated with progressive vision loss, acute orbital inflammation, and central retinal vein and artery occlusion, despite an improvement with a short course of steroids. MRI revealed enhancement of the left optic nerve, chiasm, and left optic tract. Initial optic nerve biopsy was negative and biopsy of optic tract confirmed a diagnosis of glioblastoma multiforme grade 4. The patient died 4 months after biopsy despite chemotherapy and radiotherapy.Conclusion: The diagnoses of malignant optic glioma, anterior ischemic optic neuropathy, and optic neuritis have significant overlap of signs and symptoms. The authors report a case that demonstrates the difficulties in diagnosis, and propose additional presenting features of malignant optic glioma.",

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author = "Chandra Balachandran and Millar, {Michael James} and Rajmohan Murali and Carl Bulliard and Malcolm, {Capon M.} and Anthony Maloof",

year = "2009",

doi = "10.1097/ICB.0b013e31815f3c95",

language = "English",

volume = "3",

pages = "156--160",

journal = "Retinal Cases and Brief Reports",

issn = "1935-1089",

publisher = "Lippincott Williams & Wilkins",

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T1 - Malignant optic glioma presenting as an acute anterior optic neuropathy

AU - Balachandran, Chandra

AU - Millar, Michael James

AU - Murali, Rajmohan

AU - Bulliard, Carl

AU - Malcolm, Capon M.

AU - Maloof, Anthony

PY - 2009

Y1 - 2009

N2 - Purpose: To describe an uncommon case of malignant optic glioma and the challenges in its diagnosis.Methods: Case report with funduscopic, magnetic resonance imaging (MRI), and automated field test correlations.Patient: A 60-year-old man presented with a 1-week history of left optic disk swelling and optic neuropathy that was initially diagnosed as nonarteritic anterior ischemic optic neuropathy (NA-AION).Results: His clinical course deteriorated with progressive vision loss, acute orbital inflammation, and central retinal vein and artery occlusion, despite an improvement with a short course of steroids. MRI revealed enhancement of the left optic nerve, chiasm, and left optic tract. Initial optic nerve biopsy was negative and biopsy of optic tract confirmed a diagnosis of glioblastoma multiforme grade 4. The patient died 4 months after biopsy despite chemotherapy and radiotherapy.Conclusion: The diagnoses of malignant optic glioma, anterior ischemic optic neuropathy, and optic neuritis have significant overlap of signs and symptoms. The authors report a case that demonstrates the difficulties in diagnosis, and propose additional presenting features of malignant optic glioma.

AB - Purpose: To describe an uncommon case of malignant optic glioma and the challenges in its diagnosis.Methods: Case report with funduscopic, magnetic resonance imaging (MRI), and automated field test correlations.Patient: A 60-year-old man presented with a 1-week history of left optic disk swelling and optic neuropathy that was initially diagnosed as nonarteritic anterior ischemic optic neuropathy (NA-AION).Results: His clinical course deteriorated with progressive vision loss, acute orbital inflammation, and central retinal vein and artery occlusion, despite an improvement with a short course of steroids. MRI revealed enhancement of the left optic nerve, chiasm, and left optic tract. Initial optic nerve biopsy was negative and biopsy of optic tract confirmed a diagnosis of glioblastoma multiforme grade 4. The patient died 4 months after biopsy despite chemotherapy and radiotherapy.Conclusion: The diagnoses of malignant optic glioma, anterior ischemic optic neuropathy, and optic neuritis have significant overlap of signs and symptoms. The authors report a case that demonstrates the difficulties in diagnosis, and propose additional presenting features of malignant optic glioma.

KW - Journal Article

U2 - 10.1097/ICB.0b013e31815f3c95

DO - 10.1097/ICB.0b013e31815f3c95

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C2 - 25391062

SN - 1935-1089

VL - 3

SP - 156

EP - 160

JO - Retinal Cases and Brief Reports

JF - Retinal Cases and Brief Reports

IS - 2

ER -

Malignant optic glioma presenting as an acute anterior optic neuropathy

Abstract

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