Management of chronic strongyloidiasis in immigrants and refugees

is serologic testing useful?

Beverley-Ann Biggs, Sonia Caruana, Seema Mihrshahi, Damien Jolley, Jenne Leydon, Ley Chea, Sophy Nuon

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

We assessed the usefulness of serologic testing in monitoring strongyloidiasis in immigrants after treatment with two doses of ivermectin. An observational study was conducted in a group of Cambodian immigrants residing in Melbourne who were treated for strongyloidiasis and followed-up in a general practice setting. Two doses of ivermectin (200 μg/kg) were administered orally. Periodic serologic enzyme-linked immunosorbent assay testing was undertaken for up to 30 months after treatment. Antibody titers for Strongyloides sp. decreased in 95% (38 of 40) of the patients, 47.5% (19 of 40) had a decrease in optical density to less than 0.5, and 65% (26 of 40) reached levels consistent with a cure during the follow-up period. Serologic testing for Strongyloides sp. is a useful tool for monitoring a decrease in antibody levels after effective treatment. This testing should be carried out 6–12 months after treatment to ensure a sustained downward trend suggestive of cure.
Original languageEnglish
Pages (from-to)788-791
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume80
Issue number5
DOIs
Publication statusPublished - May 2009
Externally publishedYes

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