Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice

David B. Hoyt, Richard P. Dutton, Carl J. Hauser, John R. Hess, John B. Holcomb, Yoram Kluger, Kevin MacKway-Jones, Michael J. Parr, Sandro B. Rizoli, Tetsuo Yukioka, Bertil Bouillon

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)


Background: Bleeding is one of the leading causes of preventable death after traumatic injury. Trauma-associated coagulopathy complicates the control of bleeding. The published approaches on the management of this coagulopathy differ significantly. Methods: A qualitative international survey of clinical practice among senior physicians responsible for the treatment of patients with multiple injuries (Injury Severity Score ≥16) was conducted to document common practices, highlight the variabilities, and profile the rationale behind existing clinical practices around the world. Results: Survey results are based on 80 (32%) completed returns, representing 25 countries with 93% of respondents employed by trauma centers and a mean of 20 years clinical experience. There are regional differences in the clinical specialty of physicians responsible for trauma management decisions. Blood loss, temperature, pH, platelets, prothrombin time/INR/activated partial thromboplastin time, and overall clinical assessment, were the most common criteria used to assess coagulopathy. Forty-five percent of respondents claimed to follow a massive transfusion protocol in their institution, 19% reported inconsistent protocol use and 34% do not use a protocol. The management of hypothermia, acidosis, blood products, and adjuvant therapy showed regional as well as institutional variability, and surprisingly few massive transfusion protocols specifically address these issues. Conclusions: The results of this survey may serve to draw attention to the need for a common definition of coagulopathy and standardized clinical protocols to ensure optimal patient care.

Original languageEnglish
Pages (from-to)755-765
Number of pages11
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number4
Publication statusPublished - 1 Oct 2008
Externally publishedYes


  • Clinical practice
  • Coagulopathy
  • Survey
  • Trauma


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