Management of involved or close resection margins in 120 patients with colorectal liver metastases

edge cryotherapy can achieve long-term survival

Tristan D. Yan, Ratnasari Padang, Hong Xia, Jing Zhao, Jie Li, David L. Morris*

*Corresponding author for this work

Research output: Contribution to journalArticle

15 Citations (Scopus)


Background: The liver resection margin is prognostically significant for patients with colorectal liver metastases. Management plans for patients with suboptimal resection margins have not been adequately addressed. This article reports the long-term results of edge cryotherapy in 120 patients with suboptimal resection margins. Methods: A retrospective analysis of prospectively collected clinical data of 120 patients with suboptimal hepatic resection margins was performed. Morbidity, mortality, recurrence, and survival results were analyzed. Results: The median length follow-up was 30 months (range 1 to 139). The median disease-free interval was 19 months (range 2 to 139). Cryosite, remaining liver, and extrahepatic recurrence rates were 10%, 36%, and 47%, respectively. The median survival was 39 months (range 1 to 139), and 1-, 3-, and 5-year survival rates were 89%, 55%, and 36%, respectively. Cryosite and extrahepatic recurrence were independently associated with a reduced survival outcome. Comments: Edge cryotherapy to suboptimal liver resection margins can achieve a lower local recurrence rate and a longer survival advantage.

Original languageEnglish
Pages (from-to)735-742
Number of pages8
JournalAmerican Journal of Surgery
Issue number6
Publication statusPublished - Jun 2006
Externally publishedYes


  • Colorectal liver metastasis
  • Edge cryotherapy
  • Hepatic cryotherapy
  • Liver resection

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