Mangifera indica L. (Mango) belonging to family Anacardiaceae. It is an indigenous to Indian subcontinent and an important fruit crop cultivated in tropical and subtropical regions. Its each part like pulp, peel, seed, leaves, flowers and the bark are important due to their medicinal uses. Different part of mango contains many biotic compounds like polyphenolics which can control many degenerative diseases due to their antioxidant activities. Hence, it is gaining more importance in medicinal and pharmaceutical industries. There has been tremendous interest in this plant as evidenced by the voluminous work in last few decades. This chapter will cover the medicinal uses of mango.